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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atg3tm1Kmts
targeted mutation 1, Masaaki Komatsu
MGI:5609520
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atg3tm1Kmts/Atg3tm1Kmts involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5609535
ht2
 		Atg3tm1Kmts/Atg3+ involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5609536


Genotype
MGI:5609535
hm1
Allelic
Composition		 Atg3tm1Kmts/Atg3tm1Kmts
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1Kmts mutation (0 available); any Atg3 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:215884 )
• mice delivered by Caesarian and subjected to starvation conditions die unlike wild-type mice
neonatal lethality, complete penetrance ( J:215884 )
• mice die within 1 day after birth

cellular
abnormal autophagy ( J:215884 )
• nutrient-deprived mouse embryonic fibroblasts (MEFs) exhibit a reduced rate of autophagosome-like structure formation and decreased average size of structures compared with wild-type cells
• nutrient-deprived MEFs exhibit reduced protein degradation and fail to form autolysosomes compared wild-type cells
• nutrient-deprived MEFs exhibit impaired closing step of autophagosome formation with aberrant membranous structures compared with wild-type cells
• nutrient-deprived hepatocytes contain aberrant membranous complexes resembling autophagosomes

growth/size/body
decreased birth weight ( J:215884 )

homeostasis/metabolism
abnormal autophagy ( J:215884 )
• nutrient-deprived mouse embryonic fibroblasts (MEFs) exhibit a reduced rate of autophagosome-like structure formation and decreased average size of structures compared with wild-type cells
• nutrient-deprived MEFs exhibit reduced protein degradation and fail to form autolysosomes compared wild-type cells
• nutrient-deprived MEFs exhibit impaired closing step of autophagosome formation with aberrant membranous structures compared with wild-type cells
• nutrient-deprived hepatocytes contain aberrant membranous complexes resembling autophagosomes
abnormal circulating amino acid level ( J:215884 )
• decreased total, essential and branched chain amino acids levels in the sera of mice 10 hours after delivery by Caesarian
• however, levels at delivery are normal




Genotype
MGI:5609536
ht2
Allelic
Composition		 Atg3tm1Kmts/Atg3+
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3tm1Kmts mutation (0 available); any Atg3 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagosome formation ( J:215884 )
• nutrient-deprived hepatocytes contain fewer autophagosomes compared with wild-type cells
• however, autophagosome structure is normal

homeostasis/metabolism
abnormal autophagosome formation ( J:215884 )
• nutrient-deprived hepatocytes contain fewer autophagosomes compared with wild-type cells
• however, autophagosome structure is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory