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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptbp2tm1.1Dblk
targeted mutation 1.1, Douglas Black
MGI:5607602
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Emx1tm1(cre)Ito/Emx1+
involves: 129P2/OlaHsd * 129S2/SvPas MGI:5608594
cn2
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL MGI:5608593


Genotype
MGI:5608594
cn1
Allelic
Composition
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Emx1tm1(cre)Ito/Emx1+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Ptbp2tm1.1Dblk mutation (1 available); any Ptbp2 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between P18-21

nervous system
• enlarged lateral ventricles are observed at both P5 and P11
• cortex is thinner than controls
• lamination of the olfactory bulb is highly disrupted
• olfactory bulb mitral cell layer is absent
• mice exhibit widespread neuronal death and degeneration
• widespread pyknotic nuclei are observed within the cortical plate

growth/size/body
• small size is observed as early as postnatal day 3
• pups exhibit a slower growth rate than littermates
• low body weight is observed as early postnatal day 3
• average weight is less than half of controls by P14




Genotype
MGI:5608593
cn2
Allelic
Composition
Ptbp2tm1.1Dblk/Ptbp2tm1.1Dblk
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptbp2tm1.1Dblk mutation (1 available); any Ptbp2 mutation (54 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die within one hour after birth

homeostasis/metabolism

nervous system
• major axonal tracts are absent or diminished
• anterior commissure is absent
• axonal fiber tracts in the internal and external capsules are reduced
• lateral olfactory tract is reduced





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory