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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cnot3tm1.1Tya
targeted mutation 1.1, Tadashi Yamamoto
MGI:5607530
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cnot3tm1.1Tya/Cnot3tm1.1Tya B6.129P2(Cg)-Cnot3tm1.1Tya MGI:5607533
ht2
Cnot3tm1.1Tya/Cnot3+ B6.129P2(Cg)-Cnot3tm1.1Tya MGI:5607531
cx3
Cnot3tm1.1Tya/Cnot3+
Lepob/Lepob
involves: 129P2/OlaHsd * C57BL/6J MGI:5607532


Genotype
MGI:5607533
hm1
Allelic
Composition
Cnot3tm1.1Tya/Cnot3tm1.1Tya
Genetic
Background
B6.129P2(Cg)-Cnot3tm1.1Tya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1.1Tya mutation (0 available); any Cnot3 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5607531
ht2
Allelic
Composition
Cnot3tm1.1Tya/Cnot3+
Genetic
Background
B6.129P2(Cg)-Cnot3tm1.1Tya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1.1Tya mutation (0 available); any Cnot3 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• mice fed a high-fat diet for 12 weeks show that subcutaneous fat depots are greatly decreased in mutants
• mice fed a high-fat diet for 12 weeks show that visceral fat depots are greatly decreased in mutants
• weights of adipose tissues are decreased

growth/size/body
• mice fed a high-fat diet for 12 weeks show that visceral fat depots are greatly decreased in mutants
• smaller body size that is apparent in newborns and remains throughout development
• at 12 weeks of age, mice weight about 20% less than wild-type mice
• the nose-anus length is reduced by about 5% at 12 weeks of age
• mice fed a high-fat diet for 12 weeks become less obese than wild-type mice, with weight of liver, white adipose tissue and brown adipose tissue less than that of wild-type mice on the same diet

homeostasis/metabolism
• mice fed a high-fat diet for 12 weeks become less obese than wild-type mice, with weight of liver, white adipose tissue and brown adipose tissue less than that of wild-type mice on the same diet
• mice fed a high-fat diet for 12 weeks exhibit lower blood glucose levels and remain lower in both glucose tolerance and insulin tolerance tests
• decrease in blood glucose under fasting conditions
• however, no differences in serum insulin levels
• decrease in serum triglyceride levels under feeding and fasting conditions
• whole-body oxygen consumption is higher during dark and light periods, with 24 hour oxygen consumption rates 20% higher than in wild-type mice
• however, rectal temperature is normal
• glucose tolerance test shows that blood glucose levels remain lower than in wild-type mice after glucose administration
• mice fed a high-fat diet for 12 weeks remain lower in the glucose tolerance test
• however, the insulin response was similar to wild-type mice
• mice are insulin sensitive even on a high-fat diet
• insulin tolerance test shows a greater decrease in blood glucose levels in mutants than in wild-type mice in response to insulin

integument
• mice fed a high-fat diet for 12 weeks show that subcutaneous fat depots are greatly decreased in mutants

liver/biliary system
• mice fed a high-fat diet for 12 weeks show less fatty liver development than wild-type mice

cellular
• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts

hematopoietic system
• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface

immune system
• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface

skeleton
• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface
• decrease in bone mineral density at 4 months of age
• aged mice (2 years) show a decrease in cortical bone thickness
• trabecular bone exhibits a sparse osteoporotic pattern at 4 months of age
• increase in the levels of trabecular separation and trabecular spacing at 4 months of age, which increases with age
• decrease in trabecular number at 4 months of age
• aging induced osteoporosis results in a 3-fold reduction in the baseline levels of trabecular number compared to 4 month old mutants
• decrease in trabecular bone mass at 4 months of age
• trabecular thickness is slightly reduced but is not significant, however aged mice show reduced thickness of trabecular bone
• decrease in levels of the bone volume per tissue volume at 4 months of age
• osteoporosis is exacerbated with age, with bone volume further reduced by about 50% at 2 years of age, and a further increase in trabecular separation and trabecular spacing and bone resorption
• elevation in levels of bone formation rate
• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
• mice show an increase in mineralizing surface per bone surface which represents the number of active osteoblasts per bone surface
• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface indicating that bone resorption is increased




Genotype
MGI:5607532
cx3
Allelic
Composition
Cnot3tm1.1Tya/Cnot3+
Lepob/Lepob
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1.1Tya mutation (0 available); any Cnot3 mutation (35 available)
Lepob mutation (5 available); any Lep mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are less obese than single homozygous Lepob mice

homeostasis/metabolism
• oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lepob> mice, indicating greater utilization of fat versus carbohydrates as energy source
• oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lepob> mice, indicating greater utilization of fat versus carbohydrates as energy source
• glucose tolerance is ameliorated compared to single homozygous Lepob mice
• insulin sensitivity is ameliorated compared to single homozygous Lepob mice

behavior/neurological
N
• no differences in locomotor activity or food intake compared to single homozygous Lepob mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory