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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sucla2Gt(SAbetageo)1Bhg
gene trap 1, Brett H Graham
MGI:5585619
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sucla2Gt(SAbetageo)1Bhg/Sucla2Gt(SAbetageo)1Bhg involves: 129S6/SvEvTac * C57BL/6 MGI:5585620
ht2
Sucla2Gt(SAbetageo)1Bhg/Sucla2+ involves: 129S6/SvEvTac * C57BL/6 MGI:5585621


Genotype
MGI:5585620
hm1
Allelic
Composition
Sucla2Gt(SAbetageo)1Bhg/Sucla2Gt(SAbetageo)1Bhg
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sucla2Gt(SAbetageo)1Bhg mutation (0 available); any Sucla2 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at or after E18.5 with no mice are born alive

cellular
• mouse embryonic fibroblasts exhibit mitochondria depolarization compared with wild-type cells
• in placenta, brain and muscle cells at E17.5
• progressive in mouse embryonic fibroblasts
• increased mitochondrial DNA in the brain and muscle at E15.5 and in mouse embryonic fibroblasts during the first week of culture
• perturbed mitochondria respiration in mouse embryonic fibroblasts

embryo
• signs of placenta mineralization at E17.5

growth/size/body




Genotype
MGI:5585621
ht2
Allelic
Composition
Sucla2Gt(SAbetageo)1Bhg/Sucla2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sucla2Gt(SAbetageo)1Bhg mutation (0 available); any Sucla2 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased mitochondrial DNA in mouse embryonic fibroblasts during the first week of culture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
mitochondrial DNA depletion syndrome 5 DOID:0080124 OMIM:612073
J:213453





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory