Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Endoutm1Tft mutation
(0 available);
any
Endou mutation
(28 available)
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immune system
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N |
• mice exhibit normal splenic B cell numbers and activation-induced B cell apoptosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm2Tft mutation
(1 available);
any
Cd22 mutation
(63 available)
Endoutm1Tft mutation
(0 available);
any
Endou mutation
(28 available)
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immune system
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N |
• splenic B cell numbers are restored and reversed activation-induced B cell apoptosis with normal BCR-induced blast development and proliferation compared to in Cd22tm2Tft homozygotes
• the splenic B cell anergy phenotype observed in Cd22tm2Tft homozygotes is rescued
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Endoutm1Tft mutation
(0 available);
any
Endou mutation
(28 available)
Tg(IghelMD4)4Ccg mutation
(3 available)
Tg(ML5sHEL)5Ccg mutation
(2 available)
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immune system
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N |
• B cell phenotypes observed in Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg mice are normalized
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• absent in high responder mice
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• increased anti-HEL auto-antibody production compared with control mice
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cellular
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• absent in high responder mice
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hematopoietic system
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• absent in high responder mice
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Analysis Tools
