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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mgat4btm1.1Jxm
targeted mutation 1.1, Jamey Marth
MGI:5578604
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mgat4btm1.1Jxm/Mgat4btm1.1Jxm B6.129-Mgat4btm1.1Jxm MGI:5578636
cx2
Mgat4atm1.1Jxm/Mgat4atm1.1Jxm
Mgat4btm1.1Jxm/Mgat4btm1.1Jxm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5578637


Genotype
MGI:5578636
hm1
Allelic
Composition
Mgat4btm1.1Jxm/Mgat4btm1.1Jxm
Genetic
Background
B6.129-Mgat4btm1.1Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat4btm1.1Jxm mutation (0 available); any Mgat4b mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism
• increased Protein C (factor XIV)
• reduced factor V (10-20% decrease as compared to wild-type)
• reduced factor VII (10-20% decrease as compared to wild-type
• reduced factor XII (10-20% decrease as compared to wild-type)
• increased Protein S
• reduced factor vWF (30% decrease as compared to wild-type)
• reduced factor IX (10-20% decrease as compared to wild-type)
• reduced factor VIII (30% decrease as compared to wild-type)
• reduced factor II (10-20% decrease as compared to wild-type)
• activated partial thromboplastin time (APTT) is slightly prolonged although normal prothrombin time is unaffected

immune system




Genotype
MGI:5578637
cx2
Allelic
Composition
Mgat4atm1.1Jxm/Mgat4atm1.1Jxm
Mgat4btm1.1Jxm/Mgat4btm1.1Jxm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat4atm1.1Jxm mutation (0 available); any Mgat4a mutation (23 available)
Mgat4btm1.1Jxm mutation (0 available); any Mgat4b mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory