Phenotypes associated with this allele

• Allele Symbol: Deaf1^tm1.1Mico
• Allele Name: targeted mutation 1.1, Michael Collard
• Allele ID: MGI:5576138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Deaf1^tm1.1Mico/Deaf1^tm1.1Mico Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL	MGI:5576197

Genotype
MGI:5576197

cn1

• Allelic Composition: Deaf1^tm1.1Mico/Deaf1^tm1.1Mico; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:211699 )

♂N • learn to find a visible platform in a Morris water maze with efficiency equivalent to controls

enhanced spatial learning ( J:211699 )

♂ • find a submerged platform moved to the opposite quadrant faster than controls when retested 48 hours after first exposure, but only on first trial

♂ • subsequent trials and trials 7 days later are like controls

decreased fear-related response ( J:211699 )

♂ • reduced freezing behavior in response to foot shock

♂ • significantly reduced contextual fear memory 24 hours after first test (similar result with heterozygotes)