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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp1a3tm1.1Kwk
targeted mutation 1.1, Kiyoshi Kawakami
MGI:5572809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atp1a3tm1.1Kwk/Atp1a3tm1.1Kwk B6JJcl.Cg-Atp1a3tm1.1Kwk MGI:5572812
ht2
Atp1a3tm1.1Kwk/Atp1a3+ B6JJcl.Cg-Atp1a3tm1.1Kwk MGI:5572813


Genotype
MGI:5572812
hm1
Allelic
Composition
Atp1a3tm1.1Kwk/Atp1a3tm1.1Kwk
Genetic
Background
B6JJcl.Cg-Atp1a3tm1.1Kwk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3tm1.1Kwk mutation (0 available); any Atp1a3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• due to lack of breathing movement

respiratory system
• no breathing movement at birth




Genotype
MGI:5572813
ht2
Allelic
Composition
Atp1a3tm1.1Kwk/Atp1a3+
Genetic
Background
B6JJcl.Cg-Atp1a3tm1.1Kwk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3tm1.1Kwk mutation (0 available); any Atp1a3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal paired-pulse ratio and excitatory synaptic transmissions
• response to electrical stimulation suggests decreased threshold of molecular layer interneurons
• higher frequency compared to in wild-type Purkinje cells
• however, amplitude distribution and mean amplitude are normal

behavior/neurological
• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal
• on a rotarod and a balance beam
• in home cage and open field

homeostasis/metabolism
• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal

muscle
• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory