Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation
(1 available);
any
Mecp2 mutation
(38 available)
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behavior/neurological
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• female mice exhibit hindlimb clasping by 6 months of age
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mortality/aging
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• most females die before a year, however, some females survive to more than a year
• lifespan is longer than in males
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respiratory system
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• female mice exhibit breathing irregularities by 6 months of age
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Allelic
Composition |
Mecp2tm1.1Jtc/Mecp2+
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation
(1 available);
any
Mecp2 mutation
(38 available)
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behavior/neurological
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• object memory is intact at 1 hour, but impaired at 24 hours after object training, however, the impairment occurs to a lesser degree than in males
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• females freeze for a larger percentage of time during the acquisition phase of the associative fear conditioning task as compared to wild type on day 80, but not on postnatal day 40
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• reduced latency to fall from rotarod as compared to wild type on postnatal day 30
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• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type on postnatal day 63
• reduced fine motor movements (repeated breaking of same beam) as compared to wild type on postnatal day 63
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• tonic-clonic seizures observed in 3.7% (5/136) of females
• seizures appear to be stimulated by touch
• mice die within a month of seizures
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growth/size/body
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• reduced body weight as compared to wild type on postnatal day 64
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nervous system
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• tonic-clonic seizures observed in 3.7% (5/136) of females
• seizures appear to be stimulated by touch
• mice die within a month of seizures
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Allelic
Composition |
Mecp2tm1.1Jtc/Y
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Genetic
Background |
involves: 129S6/SvEvTac * 129/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation
(1 available);
any
Mecp2 mutation
(38 available)
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behavior/neurological
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• male mice exhibit hindlimb clasping by 7 weeks of age
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• male mice exhibit hypoactivity
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• male mice exhibit forelimb stereotypies
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growth/size/body
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• male mice exhibit great variability in weight
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• some male mice exhibit failure to thrive
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• a subset of male mice have excessive weight gain
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mortality/aging
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• average lifespan in males is 85.8 +/-24.2 days
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respiratory system
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• male mice exhibit breathing irregularities by 7 weeks of age
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Allelic
Composition |
Mecp2tm1.1Jtc/Y
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jtc mutation
(1 available);
any
Mecp2 mutation
(38 available)
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behavior/neurological
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• mice appear lethargic by postnatal day 50
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• object memory is intact at 1 hour, but impaired 24 hours after object training
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• increased time spent in open arms as compared to wild type on postnatal day 25
• increased number of open arm entries as compared to wild type on on postnatal day 25
• increased travel distance in zero maze as compared to wild type control on postnatal day 25
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• males freeze for a larger percentage of time as compared to wild type on postnatal day 35, however, males freeze for smaller percentage of time on both context and cued memory tasks
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• reduced latency to fall from rotarod as compared to wild type on postnatal day 29
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• decreased forelimb grip strength as compared to wild type on postnatal day 25
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• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type first observed at postnatal day 24
• reduced fine motor movements (repeated breaking of same beam) as compared to wild type observed at postnatal day 43
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growth/size/body
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• reduced body weight as compared to wild type on postnatal day 25
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integument
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• ruffled fur observed by postnatal day 50
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respiratory system
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• respiratory abnormalities observed by postnatal day 50
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Analysis Tools