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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Clcn7tm1.1Mjec
targeted mutation 1.1, Michael J Econs
MGI:5563124
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Clcn7tm1.1Mjec/Clcn7+ involves: 129 * 129S/SvEv * C57BL/6 MGI:5563125
ht2
Clcn7tm1.1Mjec/Clcn7+ involves: 129S/SvEv * BALB/cJ * C57BL/6 MGI:5563152
ht3
Clcn7tm1.1Mjec/Clcn7+ involves: 129S/SvEv * C57BL/6 * DBA/2J MGI:5563141
ht4
Clcn7tm1.1Mawa/Clcn7tm1.1Mjec involves: 129 * C57BL/6J * C57BL/6N * CD-1 MGI:6259533


Genotype
MGI:5563125
ht1
Allelic
Composition
Clcn7tm1.1Mjec/Clcn7+
Genetic
Background
involves: 129 * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm1.1Mjec mutation (0 available); any Clcn7 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• whole areal bone mineral density at 3 months of age is very high
• Background Sensitivity: 8% increase in whole body areal bone mineral density on the 129 background compared to 4% increase on a DBA/2J background and 3.8% on a BALB/cJ background
• trabecular separation is lower

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant osteopetrosis 2 DOID:0110938 OMIM:166600
J:203761




Genotype
MGI:5563152
ht2
Allelic
Composition
Clcn7tm1.1Mjec/Clcn7+
Genetic
Background
involves: 129S/SvEv * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm1.1Mjec mutation (0 available); any Clcn7 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• Background Sensitivity: 3.8% increase in whole body areal bone mineral density on the BALB/cJ background compared to 8% increase on a 129 background and 4% on a DBA/2J background




Genotype
MGI:5563141
ht3
Allelic
Composition
Clcn7tm1.1Mjec/Clcn7+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm1.1Mjec mutation (0 available); any Clcn7 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

skeleton
• Background Sensitivity: 4% increase in whole body areal bone mineral density on the DBA/2J background compared to 8% increase on a 129 background and 3.8% on a BALB/cJ background
• trabecular separation is lower

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant osteopetrosis 2 DOID:0110938 OMIM:166600
J:203761




Genotype
MGI:6259533
ht4
Allelic
Composition
Clcn7tm1.1Mawa/Clcn7tm1.1Mjec
Genetic
Background
involves: 129 * C57BL/6J * C57BL/6N * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn7tm1.1Mawa mutation (1 available); any Clcn7 mutation (3 available)
Clcn7tm1.1Mjec mutation (0 available); any Clcn7 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by around 1 month of age

growth/size/body
• mice are runted

skeleton

craniofacial





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory