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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hcn4tm1Nnka
targeted mutation 1, Noriyuki Nakashima
MGI:5560747
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Hcn4tm1Nnka/Hcn4+ involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5560757


Genotype
MGI:5560757
ht1
Allelic
Composition
Hcn4tm1Nnka/Hcn4+
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn4tm1Nnka mutation (1 available); any Hcn4 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• thin and sparse layer in the absence of doxycycline
• fewer glomeruli in the olfactory bulb in the absence of doxycycline
• loss of glomeruli in the dorsal region in the absence of doxycycline
• however, doxycycline treatment from E1 through P28 rescues the number of glomeruli and loss of glomeruli in the dorsal region
• shorter along the rostro-caudal axis at 4 weeks in the absence of doxycycline
• smaller area around the eminence of the bulb over the transition to the olfactory tract in the absence of doxycycline
• in the absence of doxycycline, single-unit spontaneous firing rate in olfactory receptor neurons is increased compared with control mice
• however, doxycycline-treatment restores normal firing rate





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory