About   Help   FAQ
Due to maintenance, access to MGI maybe intermittent on Thu, May 23 at 7:30 AM ET.
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scn11atm1.1Ikth
targeted mutation 1.1, Ingo Kurth
MGI:5558025
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Scn11atm1.1Ikth/Scn11a+ involves: 129 * BALB/c * C57BL/6 MGI:5558028
ht2
Scn11atm1Mdba/Scn11atm1.1Ikth involves: 129 * BALB/c * C57BL/6 MGI:5558031


Genotype
MGI:5558028
ht1
Allelic
Composition
Scn11atm1.1Ikth/Scn11a+
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1.1Ikth mutation (0 available); any Scn11a mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dorsal ganglion neurons exhibit a shifted resting membrane potential indicating active channels under resting conditions compared with wild-type cell
• diminished peak current densities at depolarized voltage
• greater inward current under resting conditions
• reduced in dorsal ganglion neurons
• less pronounced in dorsal ganglion neurons
• intermediately diminished peak current densities at depolarized voltage

integument
N
• prior to induction of inflammation, mice exhibit normal withdrawal threshold for plantar mechanical and thermal stimulation
• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice
• severe, self-inflicted tissue lesions in some mice

behavior/neurological
• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary sensory neuropathy DOID:0050548 OMIM:PS162400
J:206848




Genotype
MGI:5558031
ht2
Allelic
Composition
Scn11atm1Mdba/Scn11atm1.1Ikth
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1.1Ikth mutation (0 available); any Scn11a mutation (51 available)
Scn11atm1Mdba mutation (0 available); any Scn11a mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• diminished peak current densities at depolarized voltage
• channel inactivation is more pronounced than in wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/07/2019
MGI 6.14
The Jackson Laboratory