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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ucp1-cre)1Evdr
transgene insertion 1, Evan Rosen
MGI:5550468
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+
Tg(Ucp1-cre)1Evdr/0
involves: 129 * C57BL/6J * FVB MGI:6112616
cn2
Irf4tm1Rdf/Irf4tm1Rdf
Tg(Ucp1-cre)1Evdr/0
involves: 129S1/Sv * C57BL/6J * FVB MGI:6112615
cn3
Ppargtm2Rev/Ppargtm2Rev
Tg(Ucp1-cre)1Evdr/0
involves: 129S4/SvJae * FVB MGI:6361694
cn4
Tg(Ucp1-cre)1Evdr/0
Zc3h10tm1c(EUCOMM)Wtsi/Zc3h10tm1c(EUCOMM)Wtsi
involves: 129S4/SvJaeSor * C57BL/6N * FVB MGI:6415592
cn5
Bckdhatm1a(EUCOMM)Hmgu/Bckdhatm1a(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
involves: C57BL/6N * FVB MGI:6361695
cn6
Opn3tm2c(EUCOMM)Wtsi/Opn3tm2c(EUCOMM)Wtsi
Tg(Ucp1-cre)1Evdr/0
involves: C57BL/6N * FVB MGI:6457283
cn7
Pex16tm1c(EUCOMM)Hmgu/Pex16tm1c(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
involves: C57BL/6N * FVB * SJL MGI:6682103


Genotype
MGI:6112616
cn1
Allelic
Composition
Gt(ROSA)26Sortm3(Irf4)Evdr/Gt(ROSA)26Sor+
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Irf4)Evdr mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• reduced lipogenesis in brown adipocytes
• on standard chow and a high-fat diet
• less hypertrophy when fed a high-fat diet than in control mice
• on a high-fat diet

homeostasis/metabolism
• on a high-fat diet
• on a high-fat diet
• on a high-fat diet
• on a high-fat diet

growth/size/body
• on standard chow and a high-fat diet
• on standard chow and a high-fat diet

behavior/neurological
N
• mice exhibit normal food intake and physical activity when fed standard chow or a high-fat diet

cellular
• increased uncoupled respiration in brown adipose tissue mitochondria




Genotype
MGI:6112615
cn2
Allelic
Composition
Irf4tm1Rdf/Irf4tm1Rdf
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4tm1Rdf mutation (1 available); any Irf4 mutation (18 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• reduced lipogenesis in isopropetenol-treated adipocytes
• small increased when fed standard chow
• elevated when fed a high-fat diet
• in inguinal and epididymal fat pads with increased lipid content

homeostasis/metabolism
• in cold-exposed mice
• in cold-exposed mice
• when fed a high-fat diet
• when fed a high-fat diet
• when mice are fed standard chow

growth/size/body
• small increased when fed standard chow
• elevated when fed a high-fat diet
• when fed a high-fat diet despite normal food intake

cellular
• reduced in the mitochondria of brown adipocytes despite normal mitochondrial number and cristae density




Genotype
MGI:6361694
cn3
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (32 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• composed of unilocular adipocytes and fibrotic tissues unlike in controls

homeostasis/metabolism
• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice




Genotype
MGI:6415592
cn4
Allelic
Composition
Tg(Ucp1-cre)1Evdr/0
Zc3h10tm1c(EUCOMM)Wtsi/Zc3h10tm1c(EUCOMM)Wtsi
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ucp1-cre)1Evdr mutation (1 available)
Zc3h10tm1c(EUCOMM)Wtsi mutation (0 available); any Zc3h10 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in males on a normal chow diet
• 30% decrease in oxygen consumption in brown adipose tissue from males
• temperature of brown fat in cold exposed males is markedly decreased compared to wild-type controls

growth/size/body
• in males on a normal chow diet
• in males on a normal chow diet

homeostasis/metabolism
• greater drop in body temperature in males after 3h of cold exposure compared to wild-type controls
• at all temperatures without changes in food consumption or physical activity in males
• higher glucose levels in a glucose tolerance test in males
• impaired insulin sensitivity in males during an insulin tolerance test




Genotype
MGI:6361695
cn5
Allelic
Composition
Bckdhatm1a(EUCOMM)Hmgu/Bckdhatm1a(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bckdhatm1a(EUCOMM)Hmgu mutation (0 available); any Bckdha mutation (26 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures
• in brown adipose tissue following treatment with noradrenaline
• however, muscle response is normal
• after cold exposure without affecting muscle shivering
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures
• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice

adipose tissue
• in mice fed a high-fat diet at ambient temperatures
• reduced glucose and fatty acid oxidation in brown adipose tissue of mice fed a high-fat diet at ambient temperatures

growth/size/body
• in mice fed a high-fat diet at ambient temperatures despite normal lean mass
• in mice fed a high-fat diet at ambient temperatures

liver/biliary system
• in mice fed a high-fat diet at ambient temperatures
• in mice fed a high-fat diet at ambient temperatures

behavior/neurological
N
• at ambient temperatures, mice fed a high-fat diet exhibit normal food intake

cellular
• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures




Genotype
MGI:6457283
cn6
Allelic
Composition
Opn3tm2c(EUCOMM)Wtsi/Opn3tm2c(EUCOMM)Wtsi
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3tm2c(EUCOMM)Wtsi mutation (0 available); any Opn3 mutation (15 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
N
• mice exhibit normal adaptive thermogenesis under any lighting condition




Genotype
MGI:6682103
cn7
Allelic
Composition
Pex16tm1c(EUCOMM)Hmgu/Pex16tm1c(EUCOMM)Hmgu
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: C57BL/6N * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pex16tm1c(EUCOMM)Hmgu mutation (1 available); any Pex16 mutation (18 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• reduced oxygen consumption after treatment with norepinephrine





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory