Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Irf4)Evdr mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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adipose tissue
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• reduced lipogenesis in brown adipocytes
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• on standard chow and a high-fat diet
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• less hypertrophy when fed a high-fat diet than in control mice
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homeostasis/metabolism
growth/size/body
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• on standard chow and a high-fat diet
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• on standard chow and a high-fat diet
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behavior/neurological
N |
• mice exhibit normal food intake and physical activity when fed standard chow or a high-fat diet
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cellular
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• increased uncoupled respiration in brown adipose tissue mitochondria
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4tm1Rdf mutation
(1 available);
any
Irf4 mutation
(27 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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adipose tissue
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• reduced lipogenesis in isopropetenol-treated adipocytes
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• small increased when fed standard chow
• elevated when fed a high-fat diet
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• in inguinal and epididymal fat pads with increased lipid content
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homeostasis/metabolism
growth/size/body
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• small increased when fed standard chow
• elevated when fed a high-fat diet
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• when fed a high-fat diet despite normal food intake
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cellular
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• reduced in the mitochondria of brown adipocytes despite normal mitochondrial number and cristae density
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation
(1 available);
any
Pparg mutation
(39 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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adipose tissue
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• composed of unilocular adipocytes and fibrotic tissues unlike in controls
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ucp1-cre)1Evdr mutation
(1 available)
Zc3h10tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Zc3h10 mutation
(15 available)
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adipose tissue
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• in males on a normal chow diet
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• 30% decrease in oxygen consumption in brown adipose tissue from males
• temperature of brown fat in cold exposed males is markedly decreased compared to wild-type controls
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growth/size/body
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• in males on a normal chow diet
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• in males on a normal chow diet
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a44em1Kajim mutation
(0 available);
any
Slc25a44 mutation
(10 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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adipose tissue
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• mitochondrial valine oxidation is reduced by 70% in brown adipose tissue (BAT) indicating reduced branched amino acid oxidation
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homeostasis/metabolism
growth/size/body
N |
• mice exhibit normal body weight and tissue mass of metabolic organs, including brown adipose tissue, liver, white adipose tissue, and skeletal muscle on a regular chow diet and no differences in brown adipocytes are seen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpcpd1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Gpcpd1 mutation
(33 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3tm2c(EUCOMM)Wtsi mutation
(0 available);
any
Opn3 mutation
(23 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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adipose tissue
N |
• mice exhibit normal adaptive thermogenesis under any lighting condition
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bckdhatm1a(EUCOMM)Hmgu mutation
(0 available);
any
Bckdha mutation
(33 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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homeostasis/metabolism
adipose tissue
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• in mice fed a high-fat diet at ambient temperatures
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• reduced glucose and fatty acid oxidation in brown adipose tissue of mice fed a high-fat diet at ambient temperatures
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growth/size/body
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• in mice fed a high-fat diet at ambient temperatures despite normal lean mass
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• in mice fed a high-fat diet at ambient temperatures
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liver/biliary system
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• in mice fed a high-fat diet at ambient temperatures
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• in mice fed a high-fat diet at ambient temperatures
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behavior/neurological
N |
• at ambient temperatures, mice fed a high-fat diet exhibit normal food intake
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cellular
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• in brown adipose tissue of mice fed a high-fat diet at ambient temperatures
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pex16tm1c(EUCOMM)Hmgu mutation
(1 available);
any
Pex16 mutation
(22 available)
Tg(Ucp1-cre)1Evdr mutation
(1 available)
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