Phenotypes associated with this allele

• Allele Symbol: Mycl^tm1.1Kmm
• Allele Name: targeted mutation 1.1, Kenneth Murphy
• Allele ID: MGI:5550274
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mycl^tm1.1Kmm/Mycl^tm1.1Kmm	B6.129S6(C)-Mycl^tm1.1Kmm	MGI:5550382

Genotype
MGI:5550382

hm1

• Allelic Composition: Mycl^tm1.1Kmm/Mycl^tm1.1Kmm
• Genetic Background: B6.129S6(C)-Mycl^tm1.1Kmm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased dendritic cell number ( J:206430 )

• total number and relative frequency of dendritic cells is decreased

• largest reduction is to CD103+ CD11b- conventional dendritic cells in the lung

immune system

decreased dendritic cell number ( J:206430 )

• total number and relative frequency of dendritic cells is decreased

• largest reduction is to CD103+ CD11b- conventional dendritic cells in the lung

abnormal dendritic cell physiology ( J:206430 )

• decreased proliferation of splenic CD8a+ conventional dendritic cells (cDC) as measured by BrdU incorporation (50% reduction)

• CD8a+ cDC from mice treated with the cytokine, GM-CSF, fail to exhibit improved survival

• T cell priming by dendritic cells is impaired during infection using either L. monocytogenes expressing soluble ovalbumin (LM-OVA) or VSV-OVA

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:206430 )

• mice are resistant to lethal infection by L. monocytogenes

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:206430 )

• mice are resistant to lethal infection by L. monocytogenes