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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nacc1tm1.1Jlwa
targeted mutation 1.1, Jianlong Wang
MGI:5547984
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nacc1tm1.1Jlwa/Nacc1tm1.1Jlwa involves: 129S1/Sv * C57BL/6 MGI:5547985
ht2
Nacc1tm1.1Jlwa/Nacc1+ involves: 129S1/Sv * C57BL/6 MGI:5547986


Genotype
MGI:5547985
hm1
Allelic
Composition
Nacc1tm1.1Jlwa/Nacc1tm1.1Jlwa
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nacc1tm1.1Jlwa mutation (0 available); any Nacc1 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

reproductive system

skeleton
• in some mice with the T12 phenotype
• mice exhibit a T13/L5 (jn most mice) or T12/L6 (in some mice) configuration compared with T13/L6 (in most) or T13/L5 (in few) wild-type mice
• T10, T11 and T12 in some mice exhibit high incidence of fissures affecting the dorsal surface
• T13 to a lumbar vertebrae
• missing sixth lumbar vertebrae
• in some E15 and adult mice
• fusion of all sacral vertebrae
• reduced migration
• however, proliferation is normal




Genotype
MGI:5547986
ht2
Allelic
Composition
Nacc1tm1.1Jlwa/Nacc1+
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nacc1tm1.1Jlwa mutation (0 available); any Nacc1 mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• some mice exhibit an intermediate phenotype with T13/L5 configuration compared with wild-type mice
• some mice exhibit asymmetrical partial transformation of L6 into a sacral identity
• in some E15 and adult mice
• reduced migration
• however, proliferation is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory