Phenotypes associated with this allele

• Allele Symbol: Tg(Msx2-rtTA)888Lma
• Allele Name: transgene insertion 888, Liang Ma
• Allele ID: MGI:5546504
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fgfr1^tm1Jpa/Fgfr1^tm1Jpa Fgfr2^tm1Dor/Fgfr2^tm1Dor Tg(Msx2-rtTA)888Lma/0 Tg(tetO-cre)1Jaw/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5694225
tg2	Tg(Msx2-rtTA)888Lma/?	Not Specified	MGI:5546506

Genotype
MGI:5694225

cn1

• Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa; Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(Msx2-rtTA)888Lma/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

genital tubercle hypoplasia ( J:223057 )

• underdeveloped from E11.5

• deficiency in proximodistal outgrowth at E12.5

• smaller in size at E15.5 with a lack in mesenchymal patterning

abnormal reproductive system physiology ( J:223057 )

• at E11.0, genital mesenchyme exhibits a reduction in cell proliferation compared with in wild-type mice

• however, apoptosis rates are normal

Genotype
MGI:5546506

tg2

• Allelic Composition: Tg(Msx2-rtTA)888Lma/?
• Genetic Background: Not Specified

Shortened and curly vibrissae, wavy body hairs, shortened forelimbs and interdigital webs in Tg(Msx2-rtTA)888Lma/? mice

embryo

abnormal limb bud morphology ( J:148502 )

• lack of cell death in the interdigital region of limb buds at E13.5

integument

waved hair ( J:148502 )

• pelage hairs are wavy

curly vibrissae ( J:148502 )

short vibrissae ( J:148502 )

limbs/digits/tail

abnormal limb bud morphology ( J:148502 )

• lack of cell death in the interdigital region of limb buds at E13.5

brachydactyly ( J:148502 )

• digits of the forelimbs are shorter

interdigital webbing ( J:148502 )

• interdigital webbing, especially in hindlimbs

mortality/aging

mortality/aging ( J:148502 )

N • normal life span