Phenotypes associated with this allele

• Allele Symbol: Tmem119^tm1Tfur
• Allele Name: targeted mutation 1, Takahisa Furukawa
• Allele ID: MGI:5544075
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem119^tm1Tfur/Tmem119^tm1Tfur	involves: 129S6/SvEvTac	MGI:5544079

Genotype
MGI:5544079

hm1

• Allelic Composition: Tmem119^tm1Tfur/Tmem119^tm1Tfur
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:204884 )

N • mice exhibit normal skeletal composition and membranous ossification

impaired osteoblast differentiation ( J:204884 )

• based on reduced collagen fibrils in the femoral epiphysis and altered marker expression

decreased trabecular bone volume ( J:204884 )

• at 8, but not 24, weeks

decreased compact bone thickness ( J:204884 )

• at P14 and 8 weeks, but not 24 weeks

abnormal bone trabecula morphology ( J:204884 )

• increased trabecula spacing at 8, but not 24, weeks

decreased bone trabecula number ( J:204884 )

• at 8, but not 24, weeks

decreased trabecular bone connectivity density ( J:204884 )

• at 8, but not 24, weeks

delayed endochondral bone ossification ( J:204884 )

growth/size/body

decreased body weight ( J:204884 )

• at 8 weeks

decreased body length ( J:204884 )

• at 8 weeks

postnatal growth retardation ( J:204884 )

• stunted at 8 weeks

cellular

impaired osteoblast differentiation ( J:204884 )

• based on reduced collagen fibrils in the femoral epiphysis and altered marker expression