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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbx3tm3.1Moon
targeted mutation 3.1, Anne M Moon
MGI:5538564
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
involves: 129 * C57BL/6 MGI:5538606
cn2
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 MGI:5538607
cn3
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
involves: 129 * C57BL/6 MGI:5538608


Genotype
MGI:5538606
cn1
Allelic
Composition
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(GATA6-cre)#Jbeb/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (15 available)
Tg(GATA6-cre)#Jbeb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in most mice from E12.5 to E13.5




Genotype
MGI:5538607
cn2
Allelic
Composition
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (15 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Atrioventricular block in tamoxifen treated Tbx3tm3.1Moon/Tbx3tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 mice

cardiovascular system
• in tamoxifen-treated mice
• second degree in tamoxifen-treated mice




Genotype
MGI:5538608
cn3
Allelic
Composition
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (15 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• atrial arrhythmia
• in most mice from E12.5 to E13.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory