Phenotypes associated with this allele

• Allele Symbol: Tbx3^tm3.1Moon
• Allele Name: targeted mutation 3.1, Anne M Moon
• Allele ID: MGI:5538564
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tbx3^tm3.1Moon/Tbx3^tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0	involves: 129 * C57BL/6	MGI:5538607
cn2	Tbx3^tm3.1Moon/Tbx3^tm3.1Moon Tg(GATA6-cre)#Jbeb/0	involves: 129 * C57BL/6	MGI:5538606
cn3	Tbx3^tm3.1Moon/Tbx3^tm3.1Moon Tg(Mef2c-cre)2Blk/0	involves: 129 * C57BL/6	MGI:5538608

Genotype
MGI:5538607

cn1

• Allelic Composition: Tbx3^tm3.1Moon/Tbx3^tm3.1Moon; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atrioventricular block in tamoxifen treated Tbx3^tm3.1Moon/Tbx3^tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 mice

cardiovascular system

abnormal sinus arrhythmia ( J:179977 )

• in tamoxifen-treated mice

atrioventricular block ( J:179977 )

• second degree in tamoxifen-treated mice

Genotype
MGI:5538606

cn2

• Allelic Composition: Tbx3^tm3.1Moon/Tbx3^tm3.1Moon; Tg(GATA6-cre)#Jbeb/0
• Genetic Background: involves: 129 * C57BL/6

cardiovascular system

atrioventricular block ( J:179977 )

• in most mice from E12.5 to E13.5

Genotype
MGI:5538608

cn3

• Allelic Composition: Tbx3^tm3.1Moon/Tbx3^tm3.1Moon; Tg(Mef2c-cre)2Blk/0
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:179977 )

• from E12.5 to E13.5

cardiovascular system

irregular heartbeat ( J:179977 )

• atrial arrhythmia

atrioventricular block ( J:179977 )

• in most mice from E12.5 to E13.5