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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pax6-GFP/cre)1Rilm
transgene insertion 1, Richard L Maas
MGI:5538391
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Caprin2tm2a(EUCOMM)Wtsi/Caprin2tm2a(EUCOMM)Wtsi
Tg(Pax6-GFP/cre)1Rilm/0
involves: C57BL/6J * C57BL/6NTac * FVB/N MGI:5766358
tg2
Tg(Pax6-GFP/cre)1Rilm/0 involves: FVB/N MGI:5766450


Genotype
MGI:5766358
cn1
Allelic
Composition
Caprin2tm2a(EUCOMM)Wtsi/Caprin2tm2a(EUCOMM)Wtsi
Tg(Pax6-GFP/cre)1Rilm/0
Genetic
Background
involves: C57BL/6J * C57BL/6NTac * FVB/N
Cell Lines EPD0069_4_C02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Caprin2tm2a(EUCOMM)Wtsi mutation (1 available); any Caprin2 mutation (24 available)
Tg(Pax6-GFP/cre)1Rilm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• 8% of mutant eyes display corneal opacities at variable intensities
• at P60, 60% of mutant lenses show subtle abnormalities near the putative cortical-nuclear boundary
• however, no lens opacities or overt cataracts are detected in most lenses even at the age of 6 months
• 8% (9 of 108) of mutant eyes with corneal or lens opacities also display a persistent lenti-corneal stalk, similar to Peters anomaly
• 8 of 108 mutant eyes showed a lenti-corneal stalk in a unilateral manner; one mutant exhibited this defect in both eyes
• at P60, bright field imaging revealed that a ring-like demarcation between the cortical and nuclear fiber cells is absent in most mutant lenses, unlike in control lenses
• at P30, SEM analysis showed that deep into the lens tissue mutant lenses display cortical fiber cell morphology in place of nuclear fibers
• at P0, wheat germ agglutinin (WGA) staining revealed a significantly reduced lens nucleus region relative to controls, suggesting fiber cell nuclear compaction defects
• at E12.5, E14.5 and E16.5, WGA staining intensity is higher in mutant lenses relative to control lenses, suggesting altered fiber cell membrane composition
• however, histological analysis revealed no obvious fiber cell or nuclear degradation defects at P30
• F-actin deposition is unaltered as shown by phalloidin immunostaining, suggesting normal fiber cell architecture
• no defects in lens epithelium, fiber or cell adhesion marker genes are noted at embryonic or postnatal stages
• 8% of mutant eyes display lens opacities at variable intensities




Genotype
MGI:5766450
tg2
Allelic
Composition
Tg(Pax6-GFP/cre)1Rilm/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax6-GFP/cre)1Rilm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice do not exhibit any ocular defects over an observation period of 6 months





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory