Phenotypes associated with this allele

• Allele Symbol: Tg(BEST1-cre)1Taf
• Allele Name: transgene insertion 1, Thomas A Ferguson
• Allele ID: MGI:5529527
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg5^tm1Myok/Atg5^tm1Myok Tg(BEST1-cre)1Taf/0	involves: 129S/SvEv * C57BL/6J	MGI:5554206

Genotype
MGI:5554206

cn1

• Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok; Tg(BEST1-cre)1Taf/0
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:200084 )

N • at 12 weeks of age, ERG responses are not different from wild-type littermate controls

N • no significant loss of nuclei in the outer nuclear layer by 24 weeks through 1.5 years of age

N • when control and mutant mice received an i.p. injection of 9-cis retinal and then were dark-adapted for 24 hours, scotopic and photopic electroretinogram recordings showed no significant differences in rod and cone function

decreased a-wave amplitude ( J:200084 )

• rod responses to bright-light stimuli are decreased at 16 weeks compared to controls

decreased b-wave amplitude ( J:200084 )

• cone responses to bright-light stimuli are decreased at 16 weeks compared to controls

cellular

abnormal autophagy ( J:200084 )

• in retina pigmented epithelium (RPE) cells of mutants, degenerating phagosomes with undigested photoreceptor outer segment (POS) material are observed in contrast to controls where POS are in single-membrane phagosomes

homeostasis/metabolism

abnormal autophagy ( J:200084 )

• in retina pigmented epithelium (RPE) cells of mutants, degenerating phagosomes with undigested photoreceptor outer segment (POS) material are observed in contrast to controls where POS are in single-membrane phagosomes