Phenotypes associated with this allele

• Allele Symbol: Acot7^tm1.1Mwol
• Allele Name: targeted mutation 1.1, Michael J Wolfgang
• Allele ID: MGI:5528815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acot7^tm1.1Mwol/Acot7^tm1.1Mwol Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:5528849

Genotype
MGI:5528849

cn1

• Allelic Composition: Acot7^tm1.1Mwol/Acot7^tm1.1Mwol; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:203753 )

• cold-challenged mice with or without an overnight fast maintain a higher body temperature compared with control mice

increased energy expenditure ( J:203753 )

• during a 24 hour fasting period

abnormal glucose homeostasis ( J:203753 )

• 2-fold increase in brain glucose with increased fructose-1,6-biphosphate and decreased 3-phosphoglycerate indicating altered glucose metabolism

• increased rate of glucose oxidation into carbon dioxide in the brain of fasted mice

abnormal lipid homeostasis ( J:203753 )

• increased fatty acid flux into complex lipids in the brains of fasted mice

abnormal circulating lipid level ( J:203753 )

increased fatty acids level ( J:203753 )

• nonesterified fatty acid content in the brain of fasted mice

increased circulating free fatty acids level ( J:203753 )

• in fasted mice

abnormal phospholipid level ( J:203753 )

• increased in the brain of fasted mice

increased triglyceride level ( J:203753 )

• in the brain of fasted mice

increased circulating triglyceride level ( J:203753 )

• in fasted mice

increased liver triglyceride level ( J:203753 )

• in fasted mice

behavior/neurological

behavior/neurological phenotype ( J:203753 )

N • mice fed standard chow or a high fat diet exhibit normal food intake

abnormal behavior ( J:203753 )

• during a ledge and clasp test, aged mice exhibit greater scores indicating a neurological defect compared with wild-type mice

• however, mice do not exhibit increased anxiety in an open field test

impaired coordination ( J:203753 )

• in aged mice

decreased locomotor activity ( J:203753 )

• fewer beam breaks in aged mice

hyperactivity ( J:203753 )

• during a 24 hour fasting period in young mice

nervous system

gliosis ( J:203753 )

• at 24 and 40, but not 8, weeks of age

decreased neuron number ( J:203753 )

• lower neuron cell density in the cerebellum of aged mice

neurodegeneration ( J:203753 )

• progressive

decreased prepulse inhibition ( J:203753 )

adipose tissue

increased total body fat amount ( J:203753 )

increased gonadal fat pad weight ( J:203753 )

increased inguinal fat pad weight ( J:203753 )

growth/size/body

decreased lean body mass ( J:203753 )

• without a change in fasting serum creatine kinase

liver/biliary system

increased liver triglyceride level ( J:203753 )

• in fasted mice

hepatic steatosis ( J:203753 )