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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acot7tm1.1Mwol
targeted mutation 1.1, Michael J Wolfgang
MGI:5528815
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Acot7tm1.1Mwol/Acot7tm1.1Mwol
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL MGI:5528849


Genotype
MGI:5528849
cn1
Allelic
Composition
Acot7tm1.1Mwol/Acot7tm1.1Mwol
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acot7tm1.1Mwol mutation (0 available); any Acot7 mutation (23 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• cold-challenged mice with or without an overnight fast maintain a higher body temperature compared with control mice
• during a 24 hour fasting period
• 2-fold increase in brain glucose with increased fructose-1,6-biphosphate and decreased 3-phosphoglycerate indicating altered glucose metabolism
• increased rate of glucose oxidation into carbon dioxide in the brain of fasted mice
• increased fatty acid flux into complex lipids in the brains of fasted mice
• nonesterified fatty acid content in the brain of fasted mice
• increased in the brain of fasted mice
• in the brain of fasted mice

behavior/neurological
N
• mice fed standard chow or a high fat diet exhibit normal food intake
• during a ledge and clasp test, aged mice exhibit greater scores indicating a neurological defect compared with wild-type mice
• however, mice do not exhibit increased anxiety in an open field test
• in aged mice
• during a 24 hour fasting period in young mice
• fewer beam breaks in aged mice

nervous system
• at 24 and 40, but not 8, weeks of age
• lower neuron cell density in the cerebellum of aged mice
• progressive

adipose tissue

growth/size/body
• without a change in fasting serum creatine kinase

liver/biliary system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory