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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo targeted mutation 1, Darren Moore MGI:5527542 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not exhibit abnormalities in the distribution or levels of alpha-synuclein, ubiquitin, tau, glial markers, or autophagy markers or neuronal degeneration in the brain
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• cultured midbrain dopaminergic neurons exhibit an increase in neurite complexity
• dopaminergic neurons from 20-22 month old, but not 5 month old mice, exhibit abnormal nuclei with reduced nuclear circularity
• substantia nigra pars compacta neuronal nuclei exhibit irregular shape and numerous invaginations of the nuclear envelope
• however, mice do not exhibit nigral dopaminergic neuronal loss and have normal dopaminergic nerve terminals in the striatum
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| N |
• mice exhibit normal motor behaviors in the open field and on the rotarod and normal gait
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| N |
• mice exhibit normal olfactory function
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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