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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tectatm5.1Gpr
targeted mutation 5.1, Guy P Richardson
MGI:5527096
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tectatm5.1Gpr/Tectatm5.1Gpr involves: 129S/SvEv MGI:5527176
ht2
Tectatm5.1Gpr/Tecta+ involves: 129S/SvEv MGI:5527175


Genotype
MGI:5527176
hm1
Allelic
Composition
Tectatm5.1Gpr/Tectatm5.1Gpr
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm5.1Gpr mutation (2 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hump-backed cross-sectional profile with reduced limbal attachment zone, exacerbated disruption of the marginal band




Genotype
MGI:5527175
ht2
Allelic
Composition
Tectatm5.1Gpr/Tecta+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm5.1Gpr mutation (2 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• reduced hair-bundle attachment with imprints only apparent in apical, lower-frequency regions
• Hensen's stripe is no longer attached directly to the tectorial membrane
• hump-backed tectorial membrane with reduced extent of the limbal zone and medially displaced marginal band
• most apparent changes are in the cross-sectional profile and the extent of limbal attachment
• the dense matrix is mostly missing from the severely reduced limbal zone
• collagen fibrils erupt form the upper surface of the tectorial membrane in the inner sulcal region and occasionally extend out from the lower surface in the sulcal region immediately adjacent to the limbal attachment point
• Kimura's membrane is delaminated and fenestrated
• covernet fibrils are reduced in numbers, more convoluted and run both longitudinally and radially across the surface of the tectorial membrane compared to in wild-type mice
• covernet fibrils in the sulcal and more medial regions are less tightly associated with the main body of the tectorial membrane
• the striated-sheet matrix is restricted to the lateral part of the tectorial membrane
• more severe hearing loss than in Tectatm3.1Gpr or Tectatm4.1Gpr heterozygotes
• however, increase is stable with time

behavior/neurological
• preceded by wild running

nervous system
• preceded by wild running
• reduced hair-bundle attachment with imprints only apparent in apical, lower-frequency regions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant nonsyndromic deafness 12 DOID:0110544 OMIM:601543
J:203482





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory