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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tectatm3.1Gpr
targeted mutation 3.1, Guy P Richardson
MGI:5527094
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tectatm3.1Gpr/Tectatm3.1Gpr involves: 129S/SvEv MGI:5527172
ht2
Tectatm3.1Gpr/Tecta+ involves: 129S/SvEv MGI:5527171


Genotype
MGI:5527172
hm1
Allelic
Composition
Tectatm3.1Gpr/Tectatm3.1Gpr
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm3.1Gpr mutation (2 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hump-backed cross-sectional profile with reduced limbal attachment zone, exacerbated disruption of the marginal band




Genotype
MGI:5527171
ht2
Allelic
Composition
Tectatm3.1Gpr/Tecta+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectatm3.1Gpr mutation (2 available); any Tecta mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions
• Hensen's stripe not as prominent as in wild-type mice
• Hensen's stripe lacks typical V-shape
• distorted cross-sectional profile with the limbal zone not extending fully across the surface of the spiral limbus in the medial direction, disrupted marginal band, and not as prominent Hensen's stripe as in wild-type mice
• the covernet is hard to discern with reduced fibril diameter with the presence of exceptionally large diameter fibrils
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes
• however, increase is stable with time
• less severe hearing loss than in Tectatm4.1Gpr or Tectatm5.1Gpr heterozygotes

behavior/neurological
• preceded by wild running

nervous system
• preceded by wild running
• reduced hair-bundle attachment with imprints not observed in the apical, low-frequency regions and are only apparent in more basal regions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant nonsyndromic deafness 12 DOID:0110544 OMIM:601543
J:203482





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory