All Phenotypes Usp7<tm2Wgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp7^tm2Wgu
targeted mutation 2, Wei Gu
MGI:5526104

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp7^tm2Wgu/Usp7^tm2Wgu	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5526847
cn2	Trp53^tm1Tyj/Trp53^tm1Tyj Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5526849
cn3	Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5526848

Allelic Composition	Usp7^tm2Wgu/Usp7^tm2Wgu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203102 )

N	• all mice are alive at weaning

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203102 )

nervous system

nervous system phenotype ( J:203102 )

N	• mice exhibit normal forebrain, midbrain and cerebellum size, cerebellum thickness and neural cell density

open neural tube ( J:203102 )

• in some mice

embryo

open neural tube ( J:203102 )

• in some mice

Allelic Composition	Usp7^tm2Wgu/Usp7^tm2Wgu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Usp7^tm2Wgu mutation (0 available); any Usp7 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203102 )

• 15 of 21 newborn mice die soon after birth

• all mice die by P1

nervous system

decreased brain size ( J:203102 )

• at E18.5

abnormal forebrain morphology ( J:203102 )

• flat with an almost a right angle at the midbrain junction

decreased forebrain size ( J:203102 )

• at E18.5

enlarged third ventricle ( J:203102 )

• at E18.5

thickened cerebral cortex ( J:203102 )

• at E18.5

absent cerebellum ( J:203102 )

• mostly missing at the midline at E18.5

decreased neuron number ( J:203102 )

• at E18.5

behavior/neurological

absent gastric milk in neonates ( J:203102 )

abnormal motor capabilities/coordination/movement ( J:203102 )

• uncoordinated movement at birth

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