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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTB-KRAS*G12V,-luc)#Lche
transgene insertion, Lukas C Heukamp
MGI:5526090
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Del(15Krt7-Krt18)1Tmm/+
Igs11tm1Tmm/Igs11+
Krt1ctm1Tmm/Krt1c+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5527273
cx2
Del(15Krt7-Krt18)1Tmm/+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5527266
tg3
Tg(ACTB-KRAS*G12V,-luc)#Lche/0 involves: C57BL/6 * FVB/N MGI:5526091


Genotype
MGI:5527273
cn1
Allelic
Composition
Del(15Krt7-Krt18)1Tmm/+
Igs11tm1Tmm/Igs11+
Krt1ctm1Tmm/Krt1c+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• keratin-deficient tumors are typical papillary adenomas and adenocarcinomas, exhibit similar proliferation and apoptosis rates and expression of EMT and neuroendocrine markers as seen in tumors from single Tg(Actb-KRAS*G12V,-luc)#Lche mice
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas




Genotype
MGI:5527266
cx2
Allelic
Composition
Del(15Krt7-Krt18)1Tmm/+
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice

respiratory system
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors within 6 weeks of AdCre treatment
• tumor load and size of AdCre treated mice is similar to that seen in single Tg(Actb-KRAS*G12V,-luc)#Lche mice




Genotype
MGI:5526091
tg3
Allelic
Composition
Tg(ACTB-KRAS*G12V,-luc)#Lche/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors after 6-8 weeks
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

respiratory system
• mice treated with an adenovirus expressing Cre recombinase (AdCre) develop lung tumors after 6-8 weeks
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas
• tumors in AdCre treated mice are multiple papillary adenomas and invasive papillary adenocarcinomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:199528





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory