All Phenotypes Bcr<tm1(BCR/ABL)Tsr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcr^{tm1(BCR/ABL)Tsr}
targeted mutation 1, Theodora S Ross
MGI:5524984

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺	C57BL/6-Bcr^{tm1(BCR/ABL)Tsr}	MGI:5524990
cn2	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(CMV-cre)1Cgn/0	involves: BALB/c * C57BL/6	MGI:5525099
cn3	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Runx1^tm3Dow/Runx1⁺ Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5525100
cn4	Bcr^{tm1(BCR/ABL)Tsr}/Bcr^{tm1(BCR/ABL)Tsr} Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5527191
cn5	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Vav1-cre)#Cgp/0	involves: C57BL/6	MGI:5527200
cn6	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5525098

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺
Genetic Background	C57BL/6-Bcr^{tm1(BCR/ABL)Tsr}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematopoietic stem cell number ( J:203111 )

• number of hematopoietic stem cells is decreased in young (1-3 month old) mice

abnormal bone marrow cell physiology ( J:203111 )

• bone marrow cells from mutant mice exhibit a competitive disadvantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(CMV-cre)1Cgn/0
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(CMV-cre)1Cgn mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203111 )

• mice are born at expected Mendelian rations and do not exhibit any gross abnormalities

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Runx1^tm3Dow/Runx1⁺ Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Runx1^tm3Dow mutation (0 available); any Runx1 mutation (35 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203111 )

• 50% of mice die between 6-12 months of age

hematopoietic system

increased neutrophil cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

thrombocytopenia ( J:203111 )

• prior to death mice exhibit thrombocytopenia

decreased lymphocyte cell number ( J:203111 )

• prior to death mice exhibit lymphopenia

increased monocyte cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

immune system

increased neutrophil cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

decreased lymphocyte cell number ( J:203111 )

• prior to death mice exhibit lymphopenia

increased monocyte cell number ( J:203111 )

• prior to death mice exhibit neutrophilia and/or moncytosis

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr^{tm1(BCR/ABL)Tsr} Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203111 )

• mice remained disease free throughout observation period (10-12 months)

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Vav1-cre)#Cgp/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell physiology ( J:203111 )

• bone marrow cells from mutant mice exhibit an engraftment advantage when cotransplanted into lethally irradiated mice with wild type bone marrow cells

Allelic Composition	Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcr^{tm1(BCR/ABL)Tsr} mutation (1 available); any Bcr mutation (51 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203111 )

• no hematopoietic abnormalities observed

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