All Phenotypes Fat1<tm1Fhel> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fat1^tm1Fhel
targeted mutation 1, Francoise Helmbacher
MGI:5524119

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fat1^tm1Fhel/Fat1^tm1Fhel Pax3^tm1(cre)Joe/Pax3⁺ Tg(Myl1-lacZ)1Ibdml/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5524136
cx2	Fat1^tm1Fhel/Fat1^tm1Fhel Tg(Myl1-lacZ)1Ibdml/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5524135

Allelic Composition	Fat1^tm1Fhel/Fat1^tm1Fhel Pax3^tm1(cre)Joe/Pax3⁺ Tg(Myl1-lacZ)1Ibdml/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat1^tm1Fhel mutation (0 available); any Fat1 mutation (208 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
Tg(Myl1-lacZ)1Ibdml mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Scapulohumeral muscle shape abnormalities in Fat1^tm1Fhel/Fat1^tm1Fhel Pax3^tm1(cre)Joe/Pax3⁺ Tg(Myl1-lacZ)1Ibdml/0 embryos

muscle

abnormal muscle development ( J:199157 )

• increased dispersal of myocytes at E12.5 in the fore limbs with development of ectopic muscles more so than in Fat1^tm1Fhel homozygotes but not as severe as in Fat1^tm1.2Fhel homozygotes

abnormal skeletal muscle morphology ( J:199157 )

• reduced occipital frontalis muscle and zygomatics

• unilateral or asymmetrical misplaced muscle fibers between the trapezius cervicalis and the trapezius thoracis

• additional muscles in the scapulohumoral region as in Fat1^tm1.2Fhel homozygotes without insertion of its extremity between the spinodeltoid and the triceps brachii muscles

• reduced myofiber density in the cutaneous maximus and in the subcutaneous part of the spinotrapezoid muscle

ectopic skeletal muscle ( J:199157 )