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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sema3dtm1.1Joe
targeted mutation 1.1, Jonthan Epstein
MGI:5520920
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sema3dtm1.1Joe/Sema3dtm1.1Joe involves: 129S6/SvEvTac * C57BL/6 MGI:5520921


Genotype
MGI:5520921
hm1
Allelic
Composition
Sema3dtm1.1Joe/Sema3dtm1.1Joe
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3dtm1.1Joe mutation (0 available); any Sema3d mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• pulmonary endothelial cell proliferation and survival are normal
• at E12.5, 4 of 11 mice exhibit abnormal connections of the pulmonary vein to the coronary sinus unlike wild-type mice
• at E17.5, 3 of 8 mice exhibit abnormal connections of the pulmonary vein to the coronary sinus unlike wild-type mice
• the midpharyngeal endothelial strands does not form at the proper location on the dorsal surface of the embryonic common atrium
• abnormal patterning with partial or full penetrance of the pulmonary vein connecting to the coronary sinus (right atrium) or directly to the right atrium
• however, vascular patterning at E9.5 is normal
• left to right shunt with partial or full penetrance of the pulmonary vein connecting to the coronary sinus (right atrium) or directly to the right atrium
• massively enlarged
• in mice with total anomalous pulmonary venous connection
• massively enlarged





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory