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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kdm6atm1b(EUCOMM)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5516011
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) MGI:5516063
ot2
Kdm6atm1b(EUCOMM)Wtsi/Y either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1) MGI:5516062


Genotype
MGI:5516063
hm1
Allelic
Composition
Kdm6atm1b(EUCOMM)Wtsi/Kdm6atm1b(EUCOMM)Wtsi
Genetic
Background
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1b(EUCOMM)Wtsi mutation (0 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• dead and resorbed by E12.5
• found at expected ratios at E10.5

growth/size/body
• smaller in size at E10.5

nervous system
• in the mid brain region at E10.5

cardiovascular system
• hearts small and underdeveloped
• poorly formed and incomplete
• in more severe cases

embryo
• smaller in size at E10.5
• in the mid brain region at E10.5
• reduced vascular blood

homeostasis/metabolism
• in more severe cases

muscle




Genotype
MGI:5516062
ot2
Allelic
Composition
Kdm6atm1b(EUCOMM)Wtsi/Y
Genetic
Background
either: (involves: C57BL/6 * CD-1) or (involves: 129 * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6atm1b(EUCOMM)Wtsi mutation (0 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• failure to thrive
• a small number of males survive to adulthood
• hemizygous males are reduced 83% from expected numbers
• numbers at E18.5 were as expected

growth/size/body
• small at birth
• surviving mice remain runted throughout life

nervous system
• a few exencephalic fetuses at E18.5
• otherwise, males are phenotypically normal at E18.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory