All Phenotypes Psmb11<tm1(Psmb8)Khog> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog}	involves: C57BL/6	MGI:5514413
ht2	Psmb11^{tm1(Psmb8)Khog}/Psmb11⁺	involves: C57BL/6	MGI:5514415
cx3	Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog} Psmb8^tm1Hjf/Psmb8^tm1Hjf	involves: 129P2/OlaHsd * C57BL/6	MGI:5514417
cx4	H2^dlAb1-Ea/H2^dlAb1-Ea Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog}	involves: 129S2/SvPas * C57BL/6	MGI:5514414

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:196156 )

• increased homeostatic proliferation of CD8+ T cells when transferred into irradiated or non-irradiated recipient mice

abnormal T cell differentiation ( J:196156 )

• impaired generation of CD8SP mature thymocytes and establishment of a normal CD8 T-cell pool in secondary lymphoid organs

• however, the thymus does not undergo increased negative selection and an IL5-dependent bystander effect does not account for the generation of memory phenotype CD8 T cells

abnormal T cell receptor V(D)J recombination ( J:196156 )

• altered TCR-V distribution in CD8+ T cells

decreased memory T cell number ( J:196156 )

• 2.1-fold reduction in number with an 8.1-fold decrease in naive cells in the spleen

abnormal CD8-positive, alpha beta T cell morphology ( J:196156 )

• increased percent of memory-like cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• 9.3-fold in the thymus

• in the periphery

abnormal self tolerance ( J:196156 )

• CD8+ T cells are selected for clones that are self-reactive

hematopoietic system

increased T cell proliferation ( J:196156 )

• increased homeostatic proliferation of CD8+ T cells when transferred into irradiated or non-irradiated recipient mice

abnormal T cell differentiation ( J:196156 )

• impaired generation of CD8SP mature thymocytes and establishment of a normal CD8 T-cell pool in secondary lymphoid organs

• however, the thymus does not undergo increased negative selection and an IL5-dependent bystander effect does not account for the generation of memory phenotype CD8 T cells

abnormal T cell receptor V(D)J recombination ( J:196156 )

• altered TCR-V distribution in CD8+ T cells

decreased memory T cell number ( J:196156 )

• 2.1-fold reduction in number with an 8.1-fold decrease in naive cells in the spleen

abnormal CD8-positive, alpha beta T cell morphology ( J:196156 )

• increased percent of memory-like cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• 9.3-fold in the thymus

• in the periphery

cellular

increased T cell proliferation ( J:196156 )

• increased homeostatic proliferation of CD8+ T cells when transferred into irradiated or non-irradiated recipient mice

Allelic Composition	Psmb11^{tm1(Psmb8)Khog}/Psmb11⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11^{tm1(Psmb8)Khog} mutation (0 available); any Psmb11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• 1.5-fold in the thymus

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• 1.5-fold in the thymus

Allelic Composition	Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog} Psmb8^tm1Hjf/Psmb8^tm1Hjf
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb11^{tm1(Psmb8)Khog} mutation (0 available); any Psmb11 mutation (10 available)
Psmb8^tm1Hjf mutation (2 available); any Psmb8 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog}
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (280 available)
Psmb11^{tm1(Psmb8)Khog} mutation (0 available); any Psmb11 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:196156 )

• perturbed selection at the double positive or cortical stage of CD8 T cell development

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• immature and mater thymocytes

hematopoietic system

abnormal T cell differentiation ( J:196156 )

• perturbed selection at the double positive or cortical stage of CD8 T cell development

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• immature and mater thymocytes

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