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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Braftm2.1Urr
targeted mutation 2.1, Urr R Rapp
MGI:5512688
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Braftm2.1Urr/Braftm2.1Urr involves: 129 * C57BL/6 * FVB/N MGI:5512709
cn2
Braftm2.1Urr/Braftm2.1Urr
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL MGI:5512710


Genotype
MGI:5512709
hm1
Allelic
Composition
Braftm2.1Urr/Braftm2.1Urr
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm2.1Urr mutation (0 available); any Braf mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile and showed no obvious phenotype




Genotype
MGI:5512710
cn2
Allelic
Composition
Braftm2.1Urr/Braftm2.1Urr
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm2.1Urr mutation (0 available); any Braf mutation (13 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cerebellar abnormalities in Braftm2Urr/Braftm2Urr Tg(Nes-cre)1Kln/0 and Braftm2.1Urr/Braftm2.1Urr Tg(Nes-cre)1Kln/0 mice

mortality/aging
• no mice survive beyond P28
• mice begin to die around P17

nervous system
• in the dentate granule cell layer
• however, no increase in astrocytic differentiation is observed in the dentate gyrus
• expansion of the pool of proliferating hippocampal progenitor cells in the third postnatal week
• at P10 and P20
• reduced volume of the dentate granule cell layer
• reduced volume at P21 but not P12
• cytoarchitectonic alterations affecting all lobes at P21
• irregular positions in the flocculonodular lobe LX
• Purkinje cells appear elongated
• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length
• in the flocculonodular lobe LX
• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length
• reduced glomeruli size indicating that the synapses of the granule cells with mossy fiber and Golgi cells do not form correctly
• reduced length with less well demarcated and fuzzy border
• reduced length with less well demarcated and fuzzy border
• less well demarcated and fuzzy border
• ced length with less well demarcated and fuzzy border and disorganized glomeruli

behavior/neurological
• autoaggression (biting of their toes) in 13 of 15 mice
• impaired ability to walk and balance on a rod
• however, mice walk normally otherwise
• impaired ability to walk and balance on a rod
• however, mice walk normally otherwise

growth/size/body

cellular
• in the dentate granule cell layer
• however, no increase in astrocytic differentiation is observed in the dentate gyrus
• expansion of the pool of proliferating hippocampal progenitor cells in the third postnatal week





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory