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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igsf21tm2a(EUCOMM)Hmgu
targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
MGI:5511724
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igsf21tm2a(EUCOMM)Hmgu/Igsf21tm2a(EUCOMM)Hmgu B6J;B6N-Igsf21tm2a(EUCOMM)Hmgu MGI:6119537


Genotype
MGI:6119537
hm1
Allelic
Composition
Igsf21tm2a(EUCOMM)Hmgu/Igsf21tm2a(EUCOMM)Hmgu
Genetic
Background
B6J;B6N-Igsf21tm2a(EUCOMM)Hmgu
Cell Lines HEPD0796_5_F07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igsf21tm2a(EUCOMM)Hmgu mutation (0 available); any Igsf21 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit no brain abnormalities including a normal hippocampus, symmetric and asymmetric synapse numbers, and mEPSC frequency and amplitude
• reduced total and docked synaptic vesicles in presynaptic boutons of symmetric synapses in the stratum radiatum
• slight decrease in the number of docked synaptic vesicles in the presynaptic boutons of asymmetric synapses in the perisomatic regions in the stratum pyramidale
• however, mice exhibit normal numbers of total and docked synaptic vesicles in presynaptic boutons of asymmetric synapses in the stratum radiatum and total synaptic vesicles in the presynaptic boutons of asymmetric synapses in the perisomatic regions in the stratum pyramidale
• decreased mIPSC frequency, but not amplitude
• of the acoustic startle reflex

behavior/neurological
N
• mice exhibit normal motor activity and coordination





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory