Phenotypes associated with this allele

• Allele Symbol: Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}
• Allele Name: targeted mutation 1.1, Akiko Iwasaki
• Allele ID: MGI:5510723
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgl2^tm1.1(HBEGF/EGFP)Aiwsk/Mgl2^tm1.1(HBEGF/EGFP)Aiwsk	involves: C57BL/6 * FVB/N	MGI:5510785
ht2	Mgl2^tm1.1(HBEGF/EGFP)Aiwsk/Mgl2^+	involves: C57BL/6 * FVB/N	MGI:5510786

Genotype
MGI:5510785

hm1

• Allelic Composition: Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}/Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:201044 )

N • viable

reproductive system

reproductive system phenotype ( J:201044 )

N • fertile

Genotype
MGI:5510786

ht2

• Allelic Composition: Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}/Mgl2⁺
• Genetic Background: involves: C57BL/6 * FVB/N

mortality/aging

mortality/aging ( J:201044 )

N • viable

reproductive system

reproductive system phenotype ( J:201044 )

N • fertile

immune system

decreased dendritic cell number ( J:201044 )

• depletion of Mgl2 (CD301b)+ dermal dendritic cells in skin-draining lymph nodes following injection of diphtheria toxin

decreased Langerhans cell number ( J:201044 )

• reduced frequency within the epidermis, but not skin-draining lymph nodes, following injection of diphtheria toxin

decreased B cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain

decreased CD4-positive, alpha-beta T cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain or immunized with CpG

decreased CD8-positive, alpha-beta T cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain

abnormal T-helper 2 cell morphology ( J:201044 )

• diphtheria toxin-treated mice exhibit impaired development of antigen-specific Th2 cells compared with control mice

abnormal lymph node size ( J:201044 )

• following footpad injection with papain or immunization with alum, diphtheria toxin-treated mice exhibit reduced hypertrophy of draining lymph nodes with fewer CD4+ T, CD8+ T and B cells compared to in control mice

abnormal immune system physiology ( J:201044 )

• diphtheria toxin-treated mice receiving Tg(TcraTcrb)425Cbn-expressing CD4+ T cells via adoptive transfer do not exhibit optimal screening of antigen-specific naive CD4+ T cells compared with control mice

decreased interleukin-4 secretion ( J:201044 )

• from polyclonal CD4+ T cells in draining lymph nodes of the initial injection site and lung-draining mediastinal lymph nodes

increased susceptibility to parasitic infection ( J:201044 )

• N. brasiliensis-infected diphtheria toxin-treated mice exhibit impaired development of Th2 response with impaired IL4 production compared with wild-type mice

• however, infected mice exhibit normal amounts of parasitic-specific class-switched IgG1 antibodies, follicular helper CD4+ T cells and germinal center B cells and total IgE

hematopoietic system

decreased dendritic cell number ( J:201044 )

• depletion of Mgl2 (CD301b)+ dermal dendritic cells in skin-draining lymph nodes following injection of diphtheria toxin

decreased Langerhans cell number ( J:201044 )

• reduced frequency within the epidermis, but not skin-draining lymph nodes, following injection of diphtheria toxin

decreased B cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain

decreased CD4-positive, alpha-beta T cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain or immunized with CpG

decreased CD8-positive, alpha-beta T cell number ( J:201044 )

• in draining lymph nodes of diphtheria toxin-treated mice following footpad injection with papain

abnormal T-helper 2 cell morphology ( J:201044 )

• diphtheria toxin-treated mice exhibit impaired development of antigen-specific Th2 cells compared with control mice