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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(T-cre/ERT2)1Lwd
transgene insertion 1, Mark Lewandoski
MGI:5509185
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre/ERT2)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr MGI:5509196
tg2
Tg(T-cre/ERT2)1Lwd/Tg(T-cre/ERT2)1Lwd involves: C3H/HeNCr * C57BL/6NCr MGI:5509197


Genotype
MGI:5509196
cn1
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre/ERT2)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (41 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Tg(T-cre/ERT2)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• with tamoxifen administration at E6.5, E8.5 embryos phenocopy the caudal body truncation seen with constitutive T-cre mediated inactivation
• with tamoxifen administration at E8.5, E10.5 embryos show defects in depletion of pre-somitic mesoderm (PSM) and segmentation defects, similar to embryos at E8.5
• with tamoxifen administration at E6.5 or E8.5, E8.5 and E10.5 embryos show disruption of somite patterning




Genotype
MGI:5509197
tg2
Allelic
Composition
Tg(T-cre/ERT2)1Lwd/Tg(T-cre/ERT2)1Lwd
Genetic
Background
involves: C3H/HeNCr * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre/ERT2)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygotes show no obvious defects in health or fertility





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory