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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Uba6tm1Whpr
targeted mutation 1, Wade Harper
MGI:5509054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Uba6tm1Whpr/Uba6tm1Whpr involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac MGI:5470303
cn2
Uba6tm1Whpr/Uba6tm1Whpr
Tg(Nes-cre)1Kln/0
B6.Cg-Uba6tm1Whpr Tg(Nes-cre)1Kln MGI:5511126


Genotype
MGI:5470303
hm1
Allelic
Composition
Uba6tm1Whpr/Uba6tm1Whpr
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba6tm1Whpr mutation (1 available); any Uba6 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5511126
cn2
Allelic
Composition
Uba6tm1Whpr/Uba6tm1Whpr
Tg(Nes-cre)1Kln/0
Genetic
Background
B6.Cg-Uba6tm1Whpr Tg(Nes-cre)1Kln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Uba6tm1Whpr mutation (1 available); any Uba6 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a quarter of mice that survive to P21 die within 2 months
• however, lethality is partially rescued by making food more accessible
• half of mice die between P5 and P21

behavior/neurological
• with altered response to an aversive stimulus
• in the Y-maze test
• absence of stomach content in several mice at death
• in a forced swim test, mice spend less time immobilized compared with wild-type mice
• constitutive without an alteration in body temperature
• slightly better performance on a rotarod
• in a novel environment with a lack of habituation
• pronounced in the dark phase
• aversion to nesting
• mice prefer to explore an empty chamber rather than a stranger mouse

nervous system
N
• neuronal apoptosis at E14.5 and P5 is normal
• reduced density in the CA3 region and amygdala
• in the CA3 region as early as P5, the basolateral amygdala and piriform cortex
• however, the number of neurons is normal in the CA1, dentate gyrus, cortex and cerebellar regions

homeostasis/metabolism
N
• mice exhibit normal body temperature and constant respiratory exchange ratio throughout the diurnal cycle
• hypermetabolic

growth/size/body
• at birth and 11 weeks





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory