Phenotypes associated with this allele

• Allele Symbol: Ezr^tm1Sats
• Allele Name: targeted mutation 1, Sachiko Tsukita
• Allele ID: MGI:5508539
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ezr^tm1Sats/Ezr^tm1Sats	involves: 129S4/SvJae	MGI:5508547

Genotype
MGI:5508547

hm1

• Allelic Composition: Ezr^tm1Sats/Ezr^tm1Sats
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:200366 )

• high mortality up to weaning period

digestive/alimentary system

digestive/alimentary phenotype ( J:200366 )

N • mice exhibit normal absorption of glucose, triglycerol, cholesterol and amino acids

abnormal small intestinal microvillus morphology ( J:200366 )

• sometimes slightly deformed

abnormal gastric parietal cell morphology ( J:200366 )

• following a fast, parietal cells lack invaginated apical canaliculi, with the cytoplasm filled with numerous tubulovesicles unlike in wild-type mice

• histamine treated parietal cells fail to exhibit the formation or expansion of apical secretory canaliculi unlike wild-type cells

achlorhydria ( J:200366 )

growth/size/body

decreased body weight ( J:200366 )

• however, mice exhibit partial recovery by 7 weeks

postnatal growth retardation ( J:200366 )

• severe

• however, mice exhibit partial recovery by 7 weeks

endocrine/exocrine glands

abnormal gastric parietal cell morphology ( J:200366 )

• following a fast, parietal cells lack invaginated apical canaliculi, with the cytoplasm filled with numerous tubulovesicles unlike in wild-type mice

• histamine treated parietal cells fail to exhibit the formation or expansion of apical secretory canaliculi unlike wild-type cells