Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8am10J mutation
(0 available);
any
Scn8a mutation
(99 available)
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behavior/neurological
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• generally found by 2 weeks of age
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• beginning after 2 weeks of age and progressing to paralysis
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• although no demyelination was evident in nerve cross-sections and conduction velocities were normal at 16 days of age, homozygotes display tremors, ataxia, and progressive paralysis until death by 21 to 24 days of age
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growth/size/body
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• generally evident by 2 weeks of age
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mortality/aging
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• homozygotes die between 21 and 24 days of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8am10J mutation
(0 available);
any
Scn8a mutation
(99 available)
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nervous system
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• heterozgyotes have a modest reduction in nerve conduction velocity
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Allelic Composition |
Gars1C201R/Gars1+ Scn8am10J/Scn8a+
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Genetic Background |
involves: BALB/cAnN * C3H/HeJ * FVB/NJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1C201R mutation
(2 available);
any
Gars1 mutation
(42 available)
Scn8am10J mutation
(0 available);
any
Scn8a mutation
(99 available)
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nervous system
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• neuromuscular junction innervation is decreased compared with either parental mutants, with an increase in both partial innervation and denervation
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• nerve conduction velocity is lower than in either parental mutant
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1Nmf249 mutation
(1 available);
any
Gars1 mutation
(42 available)
Scn8am10J mutation
(0 available);
any
Scn8a mutation
(99 available)
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muscle
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• slightly more severe than the parental heterozygote
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nervous system
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• decreased neuromuscular junction innervation compared with either parental heterozygotes
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• decreased relative to either parental heterozygote
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