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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nabp2tm1.1Kkha
targeted mutation 1.1, Kum Kum Khanna
MGI:5502334
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5502352
cn2
 		Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5502351


Genotype
MGI:5502352
cn1
Allelic
Composition		 Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Nabp2tm1.1Kkha mutation (1 available); any Nabp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:195140 )
N
• mice exhibit normal class switch recombination




Genotype
MGI:5502351
cn2
Allelic
Composition		 Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Nabp2tm1.1Kkha mutation (1 available); any Nabp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Testicular degeneration in Nabp2tm1.1Kkha/Nabp2tm1.1Kkha Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ mice

mortality/aging

reproductive system
reproductive system phenotype ( J:195140 )
N
• tamoxifen-treated female mice exhibit normal fertility
abnormal male germ cell morphology ( J:195140 )
• premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
oligozoospermia ( J:195140 )
• due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
• decreased elongated spermatids
abnormal male germ cell apoptosis ( J:195140 )
• in tamoxifen-treated mice
small testis ( J:195140 )
• in tamoxifen-treated mice
decreased testis weight ( J:195140 )
• in tamoxifen-treated mice
testis degeneration ( J:195140 )
• bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice
decreased litter size ( J:195140 )
• from tamoxifen-treated mice with longer intervals between litters
reduced male fertility ( J:195140 )
• in tamoxifen-treated mice

neoplasm
increased tumor incidence ( J:195140 )
• splenic and metastatic B lymphomas, T cell lymphoma in thymus, hepatocellular carcinoma and B or T lymphoblastic leukemia in 11 of 35 of tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice
increased hepatocellular carcinoma incidence ( J:195140 )
• in some tamoxifen-treated mice
increased leukemia incidence ( J:195140 )
• B or T lymphoblastic leukemia in some tamoxifen-treated mice
increased B cell derived lymphoma incidence ( J:195140 )
• splenic and metastatic B lymphomas in some tamoxifen-treated mice

cellular
abnormal male germ cell morphology ( J:195140 )
• premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
oligozoospermia ( J:195140 )
• due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
• decreased elongated spermatids
increased cellular sensitivity to ionizing radiation ( J:195140 )
• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies
• however, blood counts are normal in irradiated tamoxifen-treated mice
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
abnormal male germ cell apoptosis ( J:195140 )
• in tamoxifen-treated mice
chromosomal instability ( J:195140 )
• in tamoxifen-treated mice

growth/size/body
decreased body length ( J:195140 )
• at E14.5 and E18.5

digestive/alimentary system
abnormal small intestine morphology ( J:195140 )
• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies

immune system
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice

endocrine/exocrine glands
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
small testis ( J:195140 )
• in tamoxifen-treated mice
decreased testis weight ( J:195140 )
• in tamoxifen-treated mice
testis degeneration ( J:195140 )
• bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice

hematopoietic system
hematopoietic system phenotype ( J:195140 )
N
• blood counts are normal in irradiated tamoxifen-treated mice
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice

homeostasis/metabolism

liver/biliary system
increased hepatocellular carcinoma incidence ( J:195140 )
• in some tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory