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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nkx6-1tm1.1Msan
targeted mutation 1.1, Maike Sander
MGI:5501129
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0
involves: 129 * C57BL/6 * DBA * SJL MGI:5501188
cn2
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Tg(CAG-Bgeo/GFP)21Lbe/0
Tg(Neurog3-cre)C1Able/0
involves: 129/Sv * C57BL/6 * SJL MGI:5501186
cn3
Nkx6-1tm1.1Msan/Nkx6-1+
Pdx1tm1Cvw/Pdx1+
Tg(Neurog3-cre)C1Able/0
involves: 129/Sv * C57BL/6 * SJL MGI:5501187


Genotype
MGI:5501188
cn1
Allelic
Composition
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129 * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (6 available); any Gt(ROSA)26Sor mutation (504 available)
Nkx6-1tm1.1Msan mutation (1 available); any Nkx6-1 mutation (2 available)
Nkx6-1tm1Jlr mutation (0 available); any Nkx6-1 mutation (2 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• maintenance of beta cell is impaired with conversion to delta cell fate

cellular
• maintenance of beta cell is impaired with conversion to delta cell fate




Genotype
MGI:5501186
cn2
Allelic
Composition
Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan
Tg(CAG-Bgeo/GFP)21Lbe/0
Tg(Neurog3-cre)C1Able/0
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1tm1.1Msan mutation (1 available); any Nkx6-1 mutation (2 available)
Nkx6-1tm1Jlr mutation (0 available); any Nkx6-1 mutation (2 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Tg(Neurog3-cre)C1Able mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within the first few days after birth

endocrine/exocrine glands
N
• mice do not exhibit endocrine-to-acinar fate conversion
• beta cells exhibit normal cell proliferation and apoptosis
• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells
• due to reduced differentiation without an effect on proliferation and apoptosis

homeostasis/metabolism

cellular
• beta cell differentiation is impaired with insulin+ cells that are polyhormonal and ectopically express alpha cell markers unlike in control cells




Genotype
MGI:5501187
cn3
Allelic
Composition
Nkx6-1tm1.1Msan/Nkx6-1+
Pdx1tm1Cvw/Pdx1+
Tg(Neurog3-cre)C1Able/0
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1tm1.1Msan mutation (1 available); any Nkx6-1 mutation (2 available)
Pdx1tm1Cvw mutation (1 available); any Pdx1 mutation (22 available)
Tg(Neurog3-cre)C1Able mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit an increase in the glucagon to insulin cell ratio as in Pdx1tm1Cvw heterozygotes
• as in Pdx1tm1Cvw heterozygotes
• as in Pdx1tm1Cvw heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory