All Phenotypes Arhgef26<tm1.1Kbur> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Arhgef26^tm1.1Kbur
targeted mutation 1.1, Keith Burridge
MGI:5500046

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur	B6.Cg-Arhgef26^tm1.1Kbur	MGI:5500051
cx2	Apoe^tm1Unc/Apoe^tm1Unc Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur	B6.Cg-Arhgef26^tm1.1Kbur Apoe^tm1Unc	MGI:5500052

Allelic Composition	Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur
Genetic Background	B6.Cg-Arhgef26^tm1.1Kbur

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef26^tm1.1Kbur mutation (0 available); any Arhgef26 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal vascular endothelial cell morphology ( J:195919 )

• intimal endothelial cells exhibit reduced membrane protrusion after ICAM-1 crosslinking compared with wild-type cells

abnormal vascular endothelial cell physiology ( J:195919 )

• primary aortic endothelial cells exhibit defective activation of RhoG after ICAM-1 clustering compared with wild-type cells

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Arhgef26^tm1.1Kbur/Arhgef26^tm1.1Kbur
Genetic Background	B6.Cg-Arhgef26^tm1.1Kbur Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)
Arhgef26^tm1.1Kbur mutation (0 available); any Arhgef26 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:195919 )

• in the aortic arch descending thoracic aorta of mice fed a western diet compared with Apoe^tm1Unc homozygotes

• however, mice fed standard chow do not exhibit a significant difference

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23