Phenotypes associated with this allele

• Allele Symbol: Aloxe3^tm1.2Krie
• Allele Name: targeted mutation 1.2, Peter Krieg
• Allele ID: MGI:5496904
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aloxe3^tm1.2Krie/Aloxe3^tm1.2Krie	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:5496915

Genotype
MGI:5496915

hm1

• Allelic Composition: Aloxe3^tm1.2Krie/Aloxe3^tm1.2Krie
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:196489 )

• mice die within 5 and 12 hours of birth due to defective skin barrier function

integument

impaired skin barrier function ( J:196489 )

• at E18.5, skin remains permeable unlike in wild-type mice

• 4-fold increase in transepidermal water loss in neonates

• however, barrier function of tight junctions is normal

abnormal epidermis stratum corneum morphology ( J:196489 )

• more tightly packed than in wild-type mice

hyperkeratosis ( J:196489 )

impaired stratum corneum desquamation ( J:196489 )

• indicated by an increased occurrence of transition cells underlying the stratum corneum and occasionally irregular tubulus-like structures in the horny layers

homeostasis/metabolism

dehydration ( J:196489 )

• 4-fold increase in transepidermal water loss in neonates

impaired skin barrier function ( J:196489 )

• at E18.5, skin remains permeable unlike in wild-type mice

• 4-fold increase in transepidermal water loss in neonates

• however, barrier function of tight junctions is normal

abnormal lipid level ( J:196489 )

• mice exhibit strongly reduced levels of ester-bound ceramides in the epidermis compared with wild-type mice

growth/size/body

weight loss ( J:196489 )

• after birth, mice loss 2.5% body weight per hour unlike wild-type mice