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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPSweLon)41Ema
transgene insertion 41, Eliezer Masliah
MGI:5491622
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Thy1-APPSweLon)41Ema/0 involves: C57BL/6 * DBA/2 MGI:5491627


Genotype
MGI:5491627
tg1
Allelic
Composition
Tg(Thy1-APPSweLon)41Ema/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species
• progressive loss of synaptophysin-immunoreactive presynaptic terminals in the frontal cortex beginning at 3-4 months of age and in the hippocampus beginning at 5-7 months of age

hematopoietic system

immune system

homeostasis/metabolism
• dense amyloid deposits are seen in the frontal cortex, but not in other brain areas, at 3-4 months of age
• by 5-7 months of age, an increase in size and numbers of plaques in the frontal cortex is seen and dense amyloid deposits are seen in the subiculum of the hippocampus, thalamus, and olfactory region
• at 9-11 months of age, extensive amyloid deposits are seen in most of the neocortex, hippocampus, thalamus, and cerebellum
• amyloid deposition is seen around blood vessels and in the pial surface, accompanied by astrogliosis and microgliosis
• most plaques have abundant extracellular amyloid fibrils surrounded by dystrophic neurites containing abundant electrodense laminar bodies, vesicles and synapses
• amyloid beta 1-42 is the most abundant species

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:162842





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory