Phenotypes associated with this allele

• Allele Symbol: Pstpip2^m1Bcs
• Allele Name: mutation 1, Bai-Chuang Shyu
• Allele ID: MGI:5491057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pstpip2^m1Bcs/Pstpip2^m1Bcs	involves: C57BL/6	MGI:5491073

Genotype
MGI:5491073

hm1

• Allelic Composition: Pstpip2^m1Bcs/Pstpip2^m1Bcs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196534 )

N • mice exhibit normal motor coordination, drinking, feeding and hanging

decreased grooming behavior ( J:196534 )

decreased vertical activity ( J:196534 )

• with less contact of inflamed limb paw

decreased locomotor activity ( J:196534 )

• with less contact of inflamed limb paw

abnormal touch/ nociception ( J:196534 )

• fast or hypersensitive nociceptive response

abnormal mechanical nociception ( J:196534 )

• increased sensitivity in the von Frey test

decreased thermal nociceptive threshold ( J:196534 )

• in a tail-flick test but not in a hot plate test

immune system

abnormal microglial cell morphology ( J:196534 )

• enlarged and more fiber branching in the cerebral cortex, hippocampus and spinal cord at 5 weeks

• reduced microglia activity in the cerebral cortex, but not in the spinal cord or hippocampus, at 20 weeks

autoimmune response ( J:196534 )

• mice exhibit autoinflammation with increased proliferation in the epithelial layers of the ear, cell accumulation in the kidneys and increased megakaryocytes in the red pulp of the spleen

• however, mice exhibit normal the skin, thymus, lung, pancreas, liver, kidney, heart and joints

abnormal inflammatory response ( J:196534 )

• edematous inflammation with red, swollen, deformed paws, bone destruction and enlarged soft tissue

ear inflammation ( J:196534 )

• increased cell proliferation in the epithelial layers of the ears

skin inflammation ( J:196534 )

• in the ears and paws

integument

skin inflammation ( J:196534 )

• in the ears and paws

limbs/digits/tail

abnormal autopod morphology ( J:196534 )

• red, swollen and deformed paws at 5 to 8 weeks in fore- and hindlimbs

increased hindlimb autopod size ( J:196534 )

• thickened and dystrophic

skeleton

abnormal skeleton physiology ( J:196534 )

• bone destruction

hearing/vestibular/ear

ear inflammation ( J:196534 )

• increased cell proliferation in the epithelial layers of the ears

cellular

cellular necrosis ( J:196534 )

• of the digits

hematopoietic system

increased megakaryocyte cell number ( J:196534 )

• in the red pulp of the spleen

abnormal microglial cell morphology ( J:196534 )

• enlarged and more fiber branching in the cerebral cortex, hippocampus and spinal cord at 5 weeks

• reduced microglia activity in the cerebral cortex, but not in the spinal cord or hippocampus, at 20 weeks

nervous system

abnormal microglial cell morphology ( J:196534 )

• enlarged and more fiber branching in the cerebral cortex, hippocampus and spinal cord at 5 weeks

• reduced microglia activity in the cerebral cortex, but not in the spinal cord or hippocampus, at 20 weeks