Phenotypes associated with this allele

• Allele Symbol: Ampd2^tm1Tm
• Allele Name: targeted mutation 1, Takayuki Morisaki
• Allele ID: MGI:5490144
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ampd2^tm1Tm/Ampd2^tm1Tm	B6.129S2-Ampd2^tm1Tm	MGI:5490220
hm2	Ampd2^tm1Tm/Ampd2^tm1Tm	involves: 129S2/SvPas	MGI:5529925
cx3	Ampd2^tm1Tm/Ampd2^tm1Tm Ampd3^tm2a(KOMP)Wtsi/Ampd3^tm2a(KOMP)Wtsi	involves: 129S2/SvPas * C57BL/6N	MGI:5559171

Genotype
MGI:5490220

hm1

• Allelic Composition: Ampd2^tm1Tm/Ampd2^tm1Tm
• Genetic Background: B6.129S2-Ampd2^tm1Tm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:196782 )

• at 3 weeks of age with highest levels at 6 weeks of age

podocyte foot process effacement ( J:196782 )

• at 8, 12 and 32 weeks

abnormal renal tubule morphology ( J:196782 )

• at 12 and 24 weeks, tubules are filled with protein casts

• however, there is no obvious change in the glomerulus

homeostasis/metabolism

increased urine protein level ( J:196782 )

• at 3 weeks of age with highest levels at 6 weeks of age

Genotype
MGI:5529925

hm2

• Allelic Composition: Ampd2^tm1Tm/Ampd2^tm1Tm
• Genetic Background: involves: 129S2/SvPas

immune system

immune system phenotype ( J:201211 )

N • lung inflammation after hind limb ischemia and reperfusion is similar to controls

Genotype
MGI:5559171

cx3

• Allelic Composition: Ampd2^tm1Tm/Ampd2^tm1Tm; Ampd3^{tm2a(KOMP)Wtsi}/Ampd3^{tm2a(KOMP)Wtsi}
• Genetic Background: involves: 129S2/SvPas * C57BL/6N
• Cell Lines: EPD0043_3_B02

mortality/aging

postnatal lethality, complete penetrance ( J:200072 )

• lifespan is limited to 2 to 3 weeks

nervous system

neurodegeneration ( J:200072 )

• after P14, mostly affecting the CA3 pyramidal neurons in the hippocampus with some pyknotic cells in the cortex and cerebellum

behavior/neurological

abnormal gait ( J:200072 )

growth/size/body

decreased body weight ( J:200072 )

• slight

homeostasis/metabolism

abnormal nucleotide metabolism ( J:200072 )

• increased ATP nucleotide levels in the brain at 2 weeks

• decreased GTP nucleotide levels in the brain at 2 weeks