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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gja8R205G
Arg205Gly
MGI:5489751
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gja8R205G/Gja8R205G B6.Cg-Gja8R205G MGI:5489760
hm2
Gja8R205G/Gja8R205G CWXS/Agl-Gja8R205G MGI:5490033
hm3
Gja8R205G/Gja8R205G involves: 129S4/SvJae * CWD/LeAgl * SJL/J MGI:5489763
ht4
Gja8R205G/Gja8+ B6.Cg-Gja8R205G MGI:5489759
ht5
Gja8R205G/Gja8+ CWXS/Agl-Gja8R205G MGI:5490032
ht6
Gja8R205G/Gja8tm1Scr involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J MGI:5489761
cx7
Gja3tm1Scr/Gja3tm1Scr
Gja8R205G/Gja8R205G
involves: 129S4/SvJae * CWD/LeAgl * SJL/J MGI:5489762
ot8
Gja8R205G/? involves: CWD/LeAgl * SJL/J MGI:5489764


Genotype
MGI:5489760
hm1
Allelic
Composition
Gja8R205G/Gja8R205G
Genetic
Background
B6.Cg-Gja8R205G
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dense nuclear cataracts in Gja8R205G/Gja8R205G and Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mice but degenerating peripheral lens fibers only in Gja8R205G/Gja8R205G mice

vision/eye
• aberrant vacuole-like structures in the lens periphery

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 1 multiple types DOID:0110231 OMIM:116200
J:195727




Genotype
MGI:5490033
hm2
Allelic
Composition
Gja8R205G/Gja8R205G
Genetic
Background
CWXS/Agl-Gja8R205G
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dense nuclear cataracts in heterozygous and homozygous Gja8R205G mice and microphthalmia in homozygotes

vision/eye




Genotype
MGI:5489763
hm3
Allelic
Composition
Gja8R205G/Gja8R205G
Genetic
Background
involves: 129S4/SvJae * CWD/LeAgl * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• aberrant vacuole-like structures or enlarged extracellular spaces in the peripheral regions
• severely disrupted peripheral fiber cell organization with vacuoles and fiber degeneration




Genotype
MGI:5489759
ht4
Allelic
Composition
Gja8R205G/Gja8+
Genetic
Background
B6.Cg-Gja8R205G
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• slightly




Genotype
MGI:5490032
ht5
Allelic
Composition
Gja8R205G/Gja8+
Genetic
Background
CWXS/Agl-Gja8R205G
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dense nuclear cataracts in heterozygous and homozygous Gja8R205G mice and microphthalmia in homozygotes

vision/eye




Genotype
MGI:5489761
ht6
Allelic
Composition
Gja8R205G/Gja8tm1Scr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CWD/LeAgl * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Microphthalmia and small lenses with dense nuclear cataracts in Gja8R205G/Gja8tm1Scr mice

vision/eye




Genotype
MGI:5489762
cx7
Allelic
Composition
Gja3tm1Scr/Gja3tm1Scr
Gja8R205G/Gja8R205G
Genetic
Background
involves: 129S4/SvJae * CWD/LeAgl * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3tm1Scr mutation (0 available); any Gja3 mutation (14 available)
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dense nuclear cataracts in Gja8R205G/Gja8R205G and Gja8R205G/Gja8R205G Gja3tm1Scr/Gja3tm1Scr mice but degenerating peripheral lens fibers only in Gja8R205G/Gja8R205G mice

vision/eye
N
• mice exhibit normal lens periphery and lens fiber unlike in Gja8Nm2249 homozygotes




Genotype
MGI:5489764
ot8
Allelic
Composition
Gja8R205G/?
Genetic
Background
involves: CWD/LeAgl * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8R205G mutation (1 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• fetal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory