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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TARDBP*G348C)#Jpj
transgene insertion, Jean-Pierre Julien
MGI:5476825
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(TARDBP*G348C)#Jpj/0 involves: C3H * C57BL/6 MGI:5476838


Genotype
MGI:5476838
tg1
Allelic
Composition
Tg(TARDBP*G348C)#Jpj/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the passive avoidance test, mutants exhibit severe cognitive impairments after 7 months of age and especially in the 11th and 13th months (J:195184)
• in the passive avoidance test, mutants exhibit severe cognitive impairments after 7 months of age and especially in the 11th and 13th months (J:195184)
• mice exhibit a learning impairment in the Barnes maze test at 10 months of age, showing a reduction in the time spent in the target quadrant and increased primary errors (J:195184)
• in the probe trial, mutants show a reduction in the time spent in the target quadrant and an increase in the total number of errors (J:195184)
• mice exhibit a learning impairment in the Barnes maze test at 10 months of age, showing a reduction in the time spent in the target quadrant and increased primary errors (J:195184)
• in the probe trial, mutants show a reduction in the time spent in the target quadrant and an increase in the total number of errors (J:195184)
• mice show reduction in latency in the accelerating rotarod tests starting at around 42 weeks of age, indicating age-related motor deficits (J:195184)
• mice show reduction in latency in the accelerating rotarod tests starting at around 42 weeks of age, indicating age-related motor deficits (J:195184)

nervous system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• 10% increase (an increase of 100 axons) in the number of motor axons with 1-3 um caliber and a 12% decrease (a decrease of 120 axons) in the number of motor axons with 6-9 um caliber in 10 month old mutants (J:195184)
• 10% increase (an increase of 100 axons) in the number of motor axons with 1-3 um caliber and a 12% decrease (a decrease of 120 axons) in the number of motor axons with 6-9 um caliber in 10 month old mutants (J:195184)
• 10% of analyzed neuromuscular junctions are denervated in 10 month old mutants, while over 20% are partially denervated (J:195184)
• 10% of analyzed neuromuscular junctions are denervated in 10 month old mutants, while over 20% are partially denervated (J:195184)
• many caspase-3 positive neurons are seen in the spinal cord at 10 months of age, indicating neuronal damage (J:195184)
• many caspase-3 positive neurons are seen in the spinal cord at 10 months of age, indicating neuronal damage (J:195184)
• mice develop ubiquitinated and TARDBP+ inclusions in the spinal cord by 10 months of age (J:195184)
• abnormal accumulation of neurofilament and peripherin proteins in inclusions in large motor neurons and the brain at 10 months of age, indicating degeneration of motor neurons (J:195184)
• mice develop ubiquitinated and TARDBP+ inclusions in the spinal cord by 10 months of age (J:195184)
• abnormal accumulation of neurofilament and peripherin proteins in inclusions in large motor neurons and the brain at 10 months of age, indicating degeneration of motor neurons (J:195184)

immune system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• levels of various cytokine and chemokine mRNAs are upregulated indicating neuroinflammation (J:195184)
• levels of various cytokine and chemokine mRNAs are upregulated indicating neuroinflammation (J:195184)

hematopoietic system
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)
• age dependent microgliosis and astrogliosis in the brain and spinal cord; mircrogliosis and astrogliosis is more pronounced than in mice expressing the wild-type or the A315T transgene (J:195184)

homeostasis/metabolism
• levels of various cytokine and chemokine mRNAs are upregulated indicating neuroinflammation (J:195184)
• levels of various cytokine and chemokine mRNAs are upregulated indicating neuroinflammation (J:195184)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory