Phenotypes associated with this allele

• Allele Symbol: Neurod1^{tm1.1(Atoh7)Whk}
• Allele Name: targeted mutation 1.1, William H Klein
• Allele ID: MGI:5472139
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurod1^tm1.1(Atoh7)Whk/Neurod1^tm1.1(Atoh7)Whk	Not Specified	MGI:5472140
cx2	Atoh7^tm2Gan/Atoh7^tm2Gan Neurod1^tm1.1(Atoh7)Whk/Neurod1^tm1.1(Atoh7)Whk	Not Specified	MGI:5472141

Genotype
MGI:5472140

hm1

• Allelic Composition: Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head tilt ( J:194077 )

circling ( J:194077 )

nervous system

abnormal cerebellum morphology ( J:194077 )

• similar to mice homozygous for Neurod1^tm1Mjts

abnormal retina ganglion cell morphology ( J:194077 )

• displaced cells are found in the inner most region of the inner nuclear layer

increased retina ganglion cell number ( J:194077 )

• displaced cells are found in the inner most region of the inner nuclear layer

abnormal retina cone cell morphology ( J:194077 )

• all cone photoreceptors in the dorsal retina express the short-wavelength (S) opsin indicating a loss of M cone cells

vision/eye

abnormal retina cone cell morphology ( J:194077 )

• all cone photoreceptors in the dorsal retina express the short-wavelength (S) opsin indicating a loss of M cone cells

abnormal retina ganglion layer morphology ( J:194077 )

• increase in the density of retinal ganglion cell axon bundles in the retina at P30

abnormal retina ganglion cell morphology ( J:194077 )

• displaced cells are found in the inner most region of the inner nuclear layer

increased retina ganglion cell number ( J:194077 )

• displaced cells are found in the inner most region of the inner nuclear layer

abnormal retina inner nuclear layer morphology ( J:194077 )

• displaced retinal ganglion cells are found in the inner most region of the inner nuclear layer

Genotype
MGI:5472141

cx2

• Allelic Composition: Atoh7^tm2Gan/Atoh7^tm2Gan; Neurod1^{tm1.1(Atoh7)Whk}/Neurod1^{tm1.1(Atoh7)Whk}
• Genetic Background: Not Specified

vision/eye

decreased retina ganglion cell number ( J:194077 )

• retinas have 28% of the Isl1-positive RGCs compared to wild-type mice at E13 indicating a partial restoration of the Atoh7 null phenotype

• retinas have about 25% of the number of retinal ganglion cells as in wild-type mice

• however, cells are generated evenly across the dorsal-ventral and nasal-temporal axes

abnormal optic nerve morphology ( J:194077 )

• diameters are 20 to 40% that of wild-type optic nerves

• retinal ganglion cell axons form, fasciculate, and extend into the optic disk indicating a partial rescue of the Atoh7 null phenotype

abnormal rod electrophysiology ( J:194077 )

• dark adapted electroretinogram responses to the weakest stimuli are similar in waveform but smaller than in controls

nervous system

abnormal sensory neuron innervation pattern ( J:194077 )

• retinal ganglion cell axons project to slightly more anterior areas in the superior colliculus

decreased retina ganglion cell number ( J:194077 )

• retinas have 28% of the Isl1-positive RGCs compared to wild-type mice at E13 indicating a partial restoration of the Atoh7 null phenotype

• retinas have about 25% of the number of retinal ganglion cells as in wild-type mice

• however, cells are generated evenly across the dorsal-ventral and nasal-temporal axes

abnormal optic nerve morphology ( J:194077 )

• diameters are 20 to 40% that of wild-type optic nerves

• retinal ganglion cell axons form, fasciculate, and extend into the optic disk indicating a partial rescue of the Atoh7 null phenotype