Mouse Genome Informatics
hm1
    Atp13a2tm1Pjsch/Atp13a2tm1Pjsch
involves: 129S6/SvEvTac * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal forelimb stepping, rearing, grooming, locomotor activity and anxiety-related behaviors (J:194306)
• at 13 to 17 months, mice spend more time exploring objects during familiarization and recognition phases compared with wild-type mice
• mice take less time to walks outside of the square containing the object compared with wild-type mice
• in a Morris water maze, mice find the hidden platform faster than wild-type mice at day 2 and 3
• at 20 to 29 months of age, mice on a bean traverse challenge take more steps and make more errors while traversing the beam compared with wild-type mice
• at 20 to 29 months of age, mice exhibit decreased hindlimb stepping compared with wild-type mice
• swimming speed is increased compared to in wild-type mice
• however, performance on a beam at 5 to 12 months is normal
• unsteady at 2 years
• male, but not female, mice exhibit more variable stride lengths compared with wild-type mice
• at 20 to 29 months of age
• mice use less cotton in nest building compared with wild-type mice

nervous system
N
• mice exhibit normal striatal dopamine content in the brain (J:194306)
• at 18 months, accumulation of intraneuronal storage material (lipofuscin) in the cerebellum, hippocampus and to a lesser extent the cortex is accelerated compared to in wild-type mice
• in the hippocampus

pigmentation
• at 18 months, accumulation of intraneuronal storage material (lipofuscin) in the cerebellum, hippocampus and to a lesser extent the cortex is accelerated compared to in wild-type mice