All Phenotypes Zic3<tm2.1Jwb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic3^tm2.1Jwb/Zic3^tm2.1Jwb	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	MGI:5470167
cn2	Zic3^tm2.1Jwb/Y Tg(T-cre)1Lwd/0	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C3H * C57BL/6	MGI:5470172
cn3	Zic3^tm2.1Jwb/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:5470168
cn4	Mesp1^tm2(cre)Ysa/Mesp1⁺ Zic3^tm2.1Jwb/Y	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj	MGI:5470171
cn5	Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Zic3^tm2.1Jwb/Y	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	MGI:5470169
cn6	Zic3^tm2.1Jwb/Y H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * CBA/J	MGI:5470170
ot7	Zic3^tm2.1Jwb/Y	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J	MGI:5470166

Allelic Composition	Zic3^tm2.1Jwb/Zic3^tm2.1Jwb
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192577 )

• mice are viable and fertile and phenotypically indistinguishable from the wild-type mice

Allelic Composition	Zic3^tm2.1Jwb/Y Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation (1 available)
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:192577 )

• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning

cardiovascular system

abnormal heart looping ( J:192577 )

• in 4 of 22 mice

limbs/digits/tail

kinked tail ( J:192577 )

growth/size/body

heterotaxia ( J:192577 )

• laterality defects in 4 of 18 mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:192577 )

• despite normal numbers at E15.5, fewer than expected mice at weaning

cardiovascular system

abnormal inferior vena cava morphology ( J:192577 )

• separate entrance of hepatic veins in some mice

abnormal heart looping ( J:192577 )

• in 5 of 32 mice at E9.5

abnormal direction of heart looping ( J:192577 )

• sinisteral looping

atrial septal defect ( J:192577 )

• in some mice

abnormal heart position or orientation ( J:192577 )

• atrium isomerism in some mice

dextrocardia ( J:192577 )

• in some mice

ventricular septal defect ( J:192577 )

• in some mice

digestive/alimentary system

cleft palate ( J:192577 )

• in 4 of 38 mice at E15.5

abnormal anus morphology ( J:192577 )

• in some mice

abnormal stomach position or orientation ( J:192577 )

• midline and right-sided stomach in some mice

right-sided stomach ( J:192577 )

• in some mice

embryo

abnormal embryo development ( J:192577 )

• in some mice at E9.5

embryonic growth retardation ( J:192577 )

• in 14 of 32 mice

abnormal neural tube morphology ( J:192577 )

• in 4 of 38 mice at E15.5

growth/size/body

cleft palate ( J:192577 )

• in 4 of 38 mice at E15.5

embryonic growth retardation ( J:192577 )

• in 14 of 32 mice

heterotaxia ( J:192577 )

• laterality defects in 2 of 8 mice

right-sided stomach ( J:192577 )

• in some mice

nervous system

abnormal neural tube morphology ( J:192577 )

• in 4 of 38 mice at E15.5

exencephaly ( J:192577 )

• in 4 of 38 mice at E15.5

behavior/neurological

hindlimb paralysis ( J:192577 )

• in some mice

vision/eye

abnormal eye morphology ( J:192577 )

• in some mice

skeleton

abnormal axial skeleton morphology ( J:192577 )

• in some mice

respiratory system

abnormal lung position or orientation ( J:192577 )

• pulmonary isomerism in some mice

limbs/digits/tail

kinked tail ( J:192577 )

craniofacial

cleft palate ( J:192577 )

• in 4 of 38 mice at E15.5

Allelic Composition	Mesp1^tm2(cre)Ysa/Mesp1⁺ Zic3^tm2.1Jwb/Y
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192577 )

• mice are indistinguishable from control mice with normal survival and heart development

Allelic Composition	Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Zic3^tm2.1Jwb/Y
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192577 )

• mice are indistinguishable from control mice with normal survival and heart development

Allelic Composition	Zic3^tm2.1Jwb/Y H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192577 )

• mice are indistinguishable from control mice with normal survival and heart development

Allelic Composition	Zic3^tm2.1Jwb/Y
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic3^tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192577 )

• mice are viable and fertile and phenotypically indistinguishable from the wild-type mice

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